Induction of cytotoxicity of Pelagia noctiluca venom causes reactive oxygen species generation lipid peroxydation induction and DNA damage in human colon cancer cells

摘要

BackgroundThe long-lasting and abundant blooming of Pelagia noctiluca in Tunisian coastal waters compromises both touristic and fishing activities and causes substantial economic losses. Determining their molecular mode of action is, important in order to limit or prevent the subsequent damages. Thus, the aim of the present study was to investigate the propensity of Pelagia noctiluca venom to cause oxidative damage in HCT 116 cells and its associated genotoxic effects.