Meiosis produces haploid gametes by precisely halving the chromosome complement. Crossing over between homologous chromosomes (homologs) is essential for their accurate segregation and defects are associated with infertility, miscarriage, and congenital disease. Factors that ensure crossing over between each pair of homologs include mammalian RING-domain proteins RNF212, HEI10, and RNF212B, alleles of which are linked to infertility and heritable variation in crossover rate. This study focuses on understanding the functions and relationships between these pro-crossover RING proteins (CORs) in the mouse, providing important insights into their roles in regulating recombination, the DNA repair process that produces crossovers. Notably, chromosomal localization dynamics of the three CORs are distinct and show striking sexual dimorphism with important implications for models of crossover control.
展开▼
机译：减数分裂通过将染色体补体精确减半来产生单倍体配子。同源染色体（同源物）之间的交叉对于它们的准确分离至关重要，缺陷与不孕症、流产和先天性疾病有关。确保每对同源物之间交叉的因素包括哺乳动物 RING 结构域蛋白 RNF212、HEI10 和 RNF212B，其等位基因与不孕症和交叉率的遗传变异有关。本研究的重点是了解小鼠中这些促交叉 RING 蛋白 （COR） 的功能和关系，为它们在调节重组（产生交叉的 DNA 修复过程）中的作用提供重要见解。值得注意的是，三种 COR 的染色体定位动力学是不同的，并显示出显着的性二态性，对交叉控制模型具有重要意义。
展开▼
