Recent studies have revealed that intratumoral bacteria are active as an emerging tumor component for many unexpected tumor types beyond gastrointestinal cancers but with unclear biological functions. In this study, we provide evidence that signaling molecules from intratumor bacteria participate in cancer resistance to targeted therapy, suggesting a direct effect microbiome could perform on cancer treatment. Our finding offers insights into bacteria-tumor cross talk, providing a valuable reference for optimizing targeted therapeutic strategies.
展开▼
