Anti-cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) generates greater memory response than anti-programmed cell death protein 1 (PD-1) in tumor models. Memory T cells generated by anti-CTLA-4 demonstrate greater expansion, enhanced cytokine production, and superior antitumor activity than those from anti-PD-1. Our results illustrate that T cell factor-1 (TCF-1) is essential for memory response generated by anti-CTLA-4, whereas thymocyte selection-associated high mobility group box (TOX) deletion alone in T cells has no effect on response to anti-PD-1.
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机译：在肿瘤模型中，抗细胞毒性 T 淋巴细胞相关抗原 4 （CTLA-4） 比抗程序性细胞死亡蛋白 1 （PD-1） 产生更大的记忆反应。与抗 PD-1 相比，抗 CTLA-4 产生的记忆 T 细胞表现出更大的扩增、增强的细胞因子产生和更强的抗肿瘤活性。我们的结果表明，T 细胞因子 1 （TCF-1） 对于抗 CTLA-4 产生的记忆反应至关重要，而 T 细胞中单独的胸腺细胞选择相关的高迁移率组盒 （TOX） 缺失对抗 PD-1 的反应没有影响。
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