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A Simple Self-Maintaining Metabolic System: Robustness Autocatalysis Bistability

机译:一个简单的自我维持代谢系统:稳健性自催化性双稳态

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摘要

A living organism must not only organize itself from within; it must also maintain its organization in the face of changes in its environment and degradation of its components. We show here that a simple (M,R)-system consisting of three interlocking catalytic cycles, with every catalyst produced by the system itself, can both establish a non-trivial steady state and maintain this despite continuous loss of the catalysts by irreversible degradation. As long as at least one catalyst is present at a sufficient concentration in the initial state, the others can be produced and maintained. The system shows bistability, because if the amount of catalyst in the initial state is insufficient to reach the non-trivial steady state the system collapses to a trivial steady state in which all fluxes are zero. It is also robust, because if one catalyst is catastrophically lost when the system is in steady state it can recreate the same state. There are three elementary flux modes, but none of them is an enzyme-maintaining mode, the entire network being necessary to maintain the two catalysts.
机译:生命有机体不仅必须从内部组织起来;还必须从内部组织自身。它还必须面对环境变化和组件退化而保持其组织。我们在这里表明,由三个互锁的催化循环组成的简单(M,R)系统,系统本身产生的每种催化剂,都可以建立一个重要的稳态,并且尽管由于不可逆的降解而导致催化剂连续损失,也可以保持这种状态。 。只要至少一种催化剂在初始状态下以足够的浓度存在,就可以生产和维持其他催化剂。该系统显示出双稳态性,因为如果在初始状态下的催化剂量不足以达到非平凡的稳态,则该系统将崩溃为一个平凡的稳态,其中所有通量均为零。它也是可靠的,因为如果在系统处于稳定状态时,如果一种催化剂损失惨重,那么它可以重新创建相同的状态。存在三种基本的通量模式,但是它们都不是维持酶的模式,整个网络对于维持两种催化剂都是必需的。

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