首页>
美国卫生研究院文献>ACS Omega
>An Investigation of the Sodium Nitroprusside Effects on Serum Lipids in an Animal Model of Schizophrenia by the Magnetic Resonance Study
【2h】
An Investigation of the Sodium Nitroprusside Effects on Serum Lipids in an Animal Model of Schizophrenia by the Magnetic Resonance Study
Schizophrenia (SCZ) is a multifactorial mental illness with limited knowledge concerning pathogenesis, contributing to the lack of effective therapies. More recently, the use of a nitric oxide donor named sodium nitroprusside (sNP) was suggested as a potential therapeutic drug for the treatment of SCZ. Despite the mixed results regarding the effectiveness of the sNP in reducing SCZ symptoms, successful trials on sNP in treatment-resistant SCZ were published. We have also demonstrated the power of evaluating the lipidic profiles of human clinical and animal model samples to identify the biomarkers of the pharmacological response to the diagnosis of mental disorders. Aim of this work is to evaluate the sNP effects in an animal model for SCZ studies through lipidomic profiles assessed by magnetic resonance spectroscopy (NMR). Lipidic profiling of serum from these animals indicated a more pronounced effect of sNP on lipids in the 0.50–6.00 ppm spectral region. Chemometric analysis also indicated an approximation of the lipidic profiling of SCZ animal model rats treated with sNP compared to that of the control group. In addition, we have compared the sNP treatment with other antipsychotics classically used in the clinic, such as haloperidol and clozapine, and the sNP treatment evaluated herein confirms the potential of sNP for the treatment of SCZ.
展开▼
机译:精神分裂症 (SCZ) 是一种多因素精神疾病,对发病机制的了解有限,导致缺乏有效的治疗方法。最近,使用一种名为硝普钠 (sNP) 的一氧化氮供体被建议作为治疗 SCZ 的潜在治疗药物。尽管关于 sNP 在减轻 SCZ 症状方面的有效性结果喜忧参半,但已发表 sNP 治疗耐药性 SCZ 的成功试验。我们还证明了评估人类临床和动物模型样本的脂质谱以确定对精神障碍诊断的药理反应的生物标志物的能力。这项工作的目的是通过磁共振波谱 (NMR) 评估脂质组学谱,评估 sNP 在动物模型中对 SCZ 研究的影响。这些动物血清的脂质分析表明,sNP 对 0.50–6.00 ppm 光谱区域中的脂质的影响更明显。化学计量学分析还表明,与对照组相比,用 sNP 处理的 SCZ 动物模型大鼠的脂质分析近似。此外,我们将 sNP 治疗与临床上经典使用的其他抗精神病药(如氟哌啶醇和氯氮平)进行了比较,本文评估的 sNP 治疗证实了 sNP 治疗 SCZ 的潜力。
展开▼