Severe iatrogenic bradycardia related to the combined use of beta-blocking agents and sodium channel blockers

机译：严重的医源性心动过缓与β受体阻滞剂和钠通道阻滞剂的联合使用有关

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PurposeDrug-induced bradycardia is common during antiarrhythmic therapy; the major culprits are beta-blockers. However, whether other antiarrhythmic drugs are also a significant cause of this, alone or in combination with beta-blockers, is not well known.

机译：目的在抗心律不齐治疗期间，药物引起的心动过缓是常见的。罪魁祸首是β受体阻滞剂。但是，尚不清楚其他抗心律不齐药物是否也是单独使用或与β受体阻滞剂联用的重要原因。

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期刊名称 Clinical Pharmacology : Advances and Applications
作者
Mihoko Kawabata; Yasuhiro Yokoyama; Takeshi Sasaki; Susumu Tao; Kensuke Ihara; Yasuhiro Shirai; Tetsuo Sasano; Masahiko Goya; Tetsushi Furukawa; Mitsuaki Isobe; Kenzo Hirao;
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作者单位

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年(卷),期 2015(7),-1
年度 2015
页码 29–36
总页数 8
原文格式 PDF
正文语种
中图分类药学;
关键词
proarrhythmia elderly QRS duration;

机译：心律失常;老年人;QRS持续时间;

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专利

1. Severe iatrogenic bradycardia related to the combined use of beta-blocking agents and sodium channel blockers [J] . Mihoko Kawabata, Yasuhiro Yokoyama, Takeshi Sasaki, Clinical Pharmacology: Advances and Applications . 2015,第4S期

机译：严重的医源性心动过缓与β受体阻滞剂和钠通道阻滞剂的联合使用有关
2. Severe hyperkalemia is prevalent and can be detected by quantitative electrocardiographic findings and medication history of calcium channel blocker among the patients with symptomatic or extreme bradycardia [J] . SB Chon Critical care : . 2013,第Suppla2期

机译：严重的高钾血症很普遍，可以通过有症状或严重心动过缓的患者中的定量心电图检查结果和钙通道阻滞剂的用药史来检测
3. Design and synthesis of (5-amino-1, 2, 4-triazin-6-yl)(2-(benzo[d] isoxazol-3-yl) pyrrolidin-1-yl)methanone derivatives as sodium channel blocker and anticonvulsant agents [J] . Malik Sachin, Khan Suroor A. Journal of enzyme inhibition and medicinal chemistry. . 2014,第1a6期

机译：作为钠通道阻滞剂和抗惊厥剂的（5-氨基-1，2，2，4-三嗪-6-基）（2-（苯并[d]异恶唑-3-基）吡咯烷-1-基）甲酮衍生物的设计与合成
4. Synergistic anti-arrhythmic effects of combined blockade of sodium and ultra-rapid delayed rectifier potassium channels in human atria [C] . Haibo Ni, Dominic G. Whittaker, Wei Wang, Computing in Cardiology Conference . 2016

机译：钠和超快延迟整流钾通道联合阻断对人心房的协同抗心律失常作用
5. Use of the boundary element method in electrostatic modeling of the interaction between two blockers in sodium ion channels. [D] . Britvina, Tatiana. 2002

机译：边界元方法在钠离子通道中两个阻滞剂之间相互作用的静电建模中的应用。
6. Severe hyperkalemia is prevalent and can be detected by quantitative electrocardiographic findings and medication history of calcium channel blocker among the patients with symptomatic or extreme bradycardia [O] . SB Chon 2013

机译：严重高钾血症很普遍可以通过有症状或极度心动过缓的患者中的定量心电图检查结果和钙通道阻滞剂的用药史来检测
7. Clinical Significance of the Use-dependent Sodium channel Block and Reverse Use-dependent Potassium Channel Block of Class I and Class III Antiarrhythmic Agents and Their Values to Predict Drug Efficacy : Assessment of clinical efficacy of antiarrhthmic drugs [O] . Tsuneaki Sadanaga, Satoshi Ogawa, YutakaHanda Okada 1993

机译：使用依赖性钠通道块和逆转使用依赖性钾通道块的临床意义和III类抗心律病药及其价值观预测药物疗效：抗亚麻盐药物的临床疗效评估

Severe iatrogenic bradycardia related to the combined use of beta-blocking agents and sodium channel blockers

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