Method development and validation of ursodiol and its major metabolites in human plasma by HPLC-tandem mass spectrometry

机译：HPLC-串联质谱法测定人血浆中熊果糖及其主要代谢物的方法开发与验证

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摘要

BackgroundUrsodeoxycholic acid (UDCA) and its metabolites tauroursodeoxycholic acid (TUDCA) and glycoursodeoxycholic acid (GUDCA) have been the subject of several pharmacological studies. The objective of this study was to develop an innovative method of quantification by HPL-tandem mass spectrometry (LC-MS/MS), with a lower cost and suitable, for application in bioequivalence studies.

机译：背景熊去氧胆酸（UDCA）及其代谢物牛磺去氧胆酸（TUDCA）和糖去氧胆酸（GUDCA）已成为一些药理研究的主题。这项研究的目的是开发一种低成本，适用于生物等效性研究的，通过HPL串联质谱（LC-MS / MS）进行定量的创新方法。

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期刊名称 Clinical Pharmacology : Advances and Applications
作者
Márcio Cardoso Pinto; Danilo Chorfi Berton; Alexandre Cavenatti de Oliveira; Carolina Martins Lazaro; Silvana Aparecida Calafatti Carandina;
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作者单位

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年(卷),期 2019(11),-1
年度 2019
页码 1–13
总页数 13
原文格式 PDF
正文语种
中图分类药学;
关键词
ursodeoxycholic acid glicoursodeoxycholic acid tauroursodeoxycholic acid bioequivalence LC-MS/MS;

机译：熊去氧胆酸;葡糖去氧胆酸;牛磺去氧胆酸;生物等效性;LC-MS / MS;

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Method development and validation of ursodiol and its major metabolites in human plasma by HPLC-tandem mass spectrometry

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