Population pharmacokinetics of mefloquine piperaquine and artemether-lumefantrine in Cambodian and Tanzanian malaria patients

摘要

BackgroundInter-individual variability in plasma concentration-time profiles might contribute to differences in anti-malarial treatment response. This study investigated the pharmacokinetics of three different forms of artemisinin combination therapy (ACT) in Tanzania and Cambodia to quantify and identify potential sources of variability.