Ramipril inhibits AGE-RAGE-induced matrix metalloproteinase-2 activation in experimental diabetic nephropathy

机译：雷米普利抑制实验性糖尿病肾病中AGE-RAGE诱导的基质金属蛋白酶2活化

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BackgroundAdvanced glycation end products (AGE)-receptor for AGE (RAGE) axis and renin-angiotensin system (RAS) play a role in diabetic nephropathy (DN). Matrix metalloproteinase-2 (MMP-2) activation also contributes to DN. However, the pathological interaction among AGE-RAGE, RAS and MMP-2 in DN remains unknown. We examined here the involvement of AGE and RAS in MMP-2 activation in streptozotocin (STZ)-induced diabetic rats and in AGE-exposed rat renal proximal tubular cells (RPTCs).

机译：背景技术用于AGE（RAGE）轴的先进糖基化终产物（AGE）-受体和肾素-血管紧张素系统（RAS）在糖尿病性肾病（DN）中发挥作用。基质金属蛋白酶2（MMP-2）的激活也有助于DN。然而，DN中AGE-RAGE，RAS和MMP-2之间的病理相互作用仍然未知。我们在这里检查了AGE和RAS在链脲佐菌素（STZ）诱导的糖尿病大鼠和AGE暴露的大鼠肾近端肾小管细胞（RPTC）中MMP-2激活中的作用。

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期刊名称 Diabetology Metabolic Syndrome
作者
Kei Fukami; Sho-ichi Yamagishi; Melinda T Coughlan; Brooke E Harcourt; Phillip Kantharidis; Vicki Thallas-Bonke; Seiya Okuda; Mark E Cooper; Josephine M Forbes;
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作者单位

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年(卷),期 2014(6),-1
年度 2014
页码 86
总页数 9
原文格式 PDF
正文语种
中图分类基础医学;
关键词
Advanced glycation end products Diabetic nephropathy Renin-angiotensin system MMP-2 RAGE NF-κB;

机译：晚期糖基化终产物;糖尿病肾病;肾素-血管紧张素系统;MMP-2;RAGE;NF-κB;

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专利

1. Ramipril inhibits AGE-RAGE-induced matrix metalloproteinase-2 activation in experimental diabetic nephropathy [J] . Kei Fukami, Sho-ichi Yamagishi, Melinda T Coughlan, Diabetology and Metabolic Syndrome . 2014,第1期

机译：雷米普利抑制实验性糖尿病肾病中AGE-RAGE诱导的基质金属蛋白酶2活化
2. An imbalance between matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 contributes to the development of early diabetic nephropathy [J] . Sang Youb Han, Yi Hwa Jee, Kum Hyun Han, Nephrology Dialysis Transplantation . 2006,第9期

机译：基质金属蛋白酶-2与组织金属蛋白酶-2的组织抑制剂之间的不平衡促进了早期糖尿病肾病的发展
3. An imbalance between matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 contributes to the development of early diabetic nephropathy. [J] . Han SY, Jee YH, Han KH, Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association . 2006,第9期

机译：基质金属蛋白酶-2和组织金属蛋白酶-2的组织抑制剂之间的不平衡有助于早期糖尿病性肾病的发展。
4. Targeted Delivery of Peptide-Based Matrix Metalloproteinase-2 (MMP-2) Inhibitor in Dual Sensitive Nanoparticles with Platelet Membrane Camouflage for Ischemic Limb Treatment [C] . Yu Dang, Ning Gao, Hong Niu, Society for Biomaterials annual meeting and exposition . 2019

机译：有针对性的基于肽的基质金属蛋白酶2（MMP-2）抑制剂在带有血小板膜伪装的双敏感纳米颗粒中治疗缺血性肢体的治疗
5. Genetic and physiologic characterization of diabetic nephropathy in the type II diabetic nephropathy (T2DN) rat [D] . Schlick, Nancy Elizabeth 2006

机译：II型糖尿病肾病（T2DN）大鼠的糖尿病肾病的遗传和生理学表征
6. Ramipril can alleviate the accumulation of renal mesangial matrix inrats with diabetic nephropathy by inhibiting insulin-like growth factor-1 [O] . Wei Ren, Chen Zhao, Yan Wang, 2019

机译：雷米普利可减轻肾小球系膜基质的积累胰岛素样生长因子-1抑制糖尿病肾病大鼠
7. Ramipril inhibits AGE-RAGE-induced matrix metalloproteinase-2 activation in experimental diabetic nephropathy [O] . Fukami Kei, Yamagishi Sho-ichi, Coughlan Melinda T., 2014

机译：雷米普利抑制实验性糖尿病肾病中AGE-RAGE诱导的基质金属蛋白酶2活化

Ramipril inhibits AGE-RAGE-induced matrix metalloproteinase-2 activation in experimental diabetic nephropathy

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