Design synthesis docking and antimicrobial evaluation of some novel pyrazolo15-a pyrimidines and their corresponding cycloalkane ring-fused derivatives as purine analogs

摘要

BackgroundOver the years, pyrazolopyrimidine derivatives have been recognized as having antimicrobial activities. Recently, we reported different synthetic methods to prepare pyrazolopyrimidine derivatives as anticancer and antimicrobial agents. The studies showed that our previously reported 5-aminopyrazoles >2 act as a building block for the preparation of a variety of interesting pyrazolopyrimidines as purine analogs.