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Topical anesthetic analgesic therapy using the combination of ropivacaine and dexmedetomidine: hyaluronic acid modified long-acting nanostructured lipid carriers containing a skin penetration enhancer

机译：罗哌卡因和右美托咪定联合使用的局部麻醉镇痛药：透明质酸修饰的长效纳米结构脂质载体含有皮肤渗透促进剂

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PurposeHyaluronic acid-poly(ethylene glycol)-distearoyl phosphoethanolamine (HA-PEG-DSPE) modified and tocopheryl polyethylene glycol 1000 succinate (TPGS) contained nanostructured lipid carriers (NLCs) were prepared loading ropivacaine and dexmedetomidine to improve the topical anesthetic analgesic anesthesia efficiency.

机译：目的制备透明质酸-聚（乙二醇）-二硬脂酰磷酸乙醇胺（HA-PEG-DSPE）改性和生育酚聚乙二醇1000琥珀酸酯（TPGS）含有纳米结构脂质载体（NLC），以负载罗哌卡因和右美托咪定以提高局部麻醉药的镇痛麻醉效率。

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期刊名称 Drug Design Development and Therapy
作者
Yongjian Yang; Dahai Qiu; Yajun Liu; Lei Chao;
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作者单位

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年(卷),期 2019(13),-1
年度 2019
页码 3307–3319
总页数 13
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
topical anesthetic analgesic skin penetration hyaluronic acid long-acting nanostructured lipid carriers tocopheryl polyethylene glycol 1000 succinate;

机译：局部麻醉药;皮肤渗透;透明质酸;长效纳米结构脂质载体;生育酚聚乙二醇1000琥珀酸酯;

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专利

1. Topical anesthetic analgesic therapy using the combination of ropivacaine and dexmedetomidine: hyaluronic acid modified long-acting nanostructured lipid carriers containing a skin penetration enhancer [J] . Yongjian Yang, Dahai Qiu, Yajun Liu, Drug Design, Development and Therapy . 2019,第4期

机译：罗哌卡因和右美托咪定联合使用的局部麻醉镇痛药：透明质酸修饰的长效纳米结构脂质载体，含有皮肤渗透促进剂
2. Design and evaluation of lidocaine- and prilocaine-coloaded nanoparticulate drug delivery systems for topical anesthetic analgesic therapy: a comparison between solid lipid nanoparticles and nanostructured lipid carriers [J] . Peijun You, Ran Yuan, Chuanyu Chen Drug Design, Development and Therapy . 2017,第5期

机译：利多卡因和丙胺卡因负载的纳米颗粒药物递送系统的设计和评估，用于局部麻醉镇痛：固体脂质纳米颗粒与纳米结构脂质载体的比较
3. Dexmedetomidine and levobupivacaine co-loaded, transcriptional transactivator peptide modified nanostructured lipid carriers or lipid–polymer hybrid nanoparticles, which performed better for local anesthetic therapy? [J] . Min Li, Shuo Feng, Huaixin Xing, Drug delivery. . 2020,第1期

机译：德克梅哌啶胺和左旋普替昔芬肽加载转录转段肽肽改性纳米结构脂质载体或脂质 - 聚合物杂交纳米颗粒，对局部麻醉治疗表现较好吗？
4. Solid Lipid Nanoparticles as Penetration Enhancer and Carrier System for Topical Ibuprofen Delivery [C] . Patel Vishnu, Xudong Yuan Annual meeting exposition of the Controlled Release Society . 2010

机译：固体脂质纳米颗粒作为布洛芬局部给药的渗透促进剂和载体系统
5. Design and evaluation of lidocaine- and prilocaine-coloaded nanoparticulate drug delivery systems for topical anesthetic analgesic therapy: a comparison between solid lipid nanoparticles and nanostructured lipid carriers [O] . Peijun You, Ran Yuan, Chuanyu Chen 2017

机译：利多卡因和丙胺卡因负载的纳米颗粒药物递送系统的设计和评估用于局部麻醉镇痛：固体脂质纳米颗粒与纳米结构脂质载体的比较
6. Design and evaluation of lidocaine- and prilocaine-coloaded nanoparticulate drug delivery systems for topical anesthetic analgesic therapy: a comparison between solid lipid nanoparticles and nanostructured lipid carriers [O] . Peijun You, Ran Yuan, Chuanyu Chen 2017

机译：用于局部麻醉镇痛治疗的LIDOCAINE-和PRILOCAINE-COOLODED纳米颗粒药物递送系统的设计与评价：固体脂质纳米粒子和纳米结构脂质载体之间的比较

Topical anesthetic analgesic therapy using the combination of ropivacaine and dexmedetomidine: hyaluronic acid modified long-acting nanostructured lipid carriers containing a skin penetration enhancer

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