Solid Lipid Nanoparticles as Penetration Enhancer and Carrier System for Topical Ibuprofen Delivery

摘要

There is no topical formulation of ibuprofen available till date. Solid lipid nanoparticles (SLNs) were used as carrier system to provide localized ibuprofen delivery for effective pain management. Ibuprofen SLNs were prepared by hot homogenization method with different ratios of lipids and surfactants. Formulations were characterized for drug entrapment, particle size distribution, zeta potential and Transmission electron microscopy (TEM). DSC and FTIR were carried out to ensure drug encapsulation in the lipid matrix. In-vitro studies were carried out using Franz diffusion cell. It was observed that the drug was successfully encapsulated in the matrix and found to be compatible with the lipids and surfactants. The drug was found to be in amorphous form in the matrix and showed controlled release over the period of 48 hours in the in-vitro study. In conclusion the SLN of Ibuprofen may be the choice of therapy for long term pain management.