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A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles

机译：两种伏立康唑制剂的药代动力学比较以及CYP2C19多态性对其药代动力学特征的影响

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摘要

PurposeSYP-1018 is a lyophilized polymeric nanoparticle formulation of voriconazole that is under development for intravenous dosing. This study compared the pharmacokinetic and tolerability profiles of SYP-1018 with those of Vfend^®, the marketed formulation of voriconazole. The effect of CYP2C19 polymorphism on the voriconazole pharmacokinetics was also evaluated.

机译：目的SYP-1018是伏立康唑的冻干聚合物纳米颗粒制剂，目前正在开发中，可用于静脉内给药。这项研究比较了SYP-1018与伏立康唑市售制剂Vfend ^{®的药代动力学和耐受性。还评价了CYP2C19多态性对伏立康唑药代动力学的影响。}

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期刊名称 Drug Design Development and Therapy
作者
Hyewon Chung; Howard Lee; HyeKyung Han; Hyungmi An; Kyoung Soo Lim; Yong Jin Lee; Joo-Youn Cho; Seo Hyun Yoon; In-Jin Jang; Kyung-Sang Yu;
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作者单位

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年(卷),期 2015(9),-1
年度 2015
页码 2609–2616
总页数 8
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
voriconazole pharmacokinetics pharmacogenetics CYP2C19;

机译：伏立康唑;药代动力学;药物遗传学;CYP2C19;

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1. A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles [J] . Hyewon Chung, Howard Lee, HyeKyung Han, Drug Design, Development and Therapy . 2015,第9期

机译：两种伏立康唑制剂的药代动力学比较以及CYP2C19多态性对其药代动力学特征的影响
2. COMPARISON OF THE PHARMACOKINETICS BETWEEN TWO VORICONAZOLE FORMULATIONS AND THE EFFECT OF CYP2C19 POLYMORPHISMS ON VORICONAZOLE EXPOSURE. [J] . Lee J., Han H., Shin D., Clinical Pharmacology and Therapeutics . 2014,第Suppla1期

机译：两种伏立康唑制剂的药代动力学比较和CYP2C19多态性对伏立康唑暴露的影响。
3. Population pharmacokinetics of voriconazole and CYP2C19 CYP2C19 polymorphisms for optimizing dosing regimens in renal transplant recipients [J] . Lin Xiao‐bin, Li Zi‐wei, Yan Miao, British Journal of Clinical Pharmacology . 2018,第7期

机译：用于优化肾移植受者的剂量方案的voriconazole和Cyp2C19 Cyp2C19多态性的人口药代动力学
4. ASSOCIATION OF CYP3A4 * 18B POLYMORPHISMS WITH THE PHARMACOKINETICS OF TACROLIMUS IN CHINESE RENAL TRANSPLANT RECIPIENTS [C] . Li Danying, Fang Yun, Teng Ruichen Progress on post-genome technologies and modern natural products . 2011

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机译：1.胃肠道转运对肠溶微丸制剂中药物药代动力学的影响的药代动力学建模和模拟及其应用。 2.开发可压碎的肠溶衣制剂。 3.开发泄漏的肠溶丸剂。
6. Selection of 12‐Hour Sustained‐Release Acetaminophen (Paracetamol) Formulation Through Comparison of Pharmacokinetic Profiles of 4 Sustained‐Release Prototype Formulations and Standard Acetaminophen Formulation: An Open‐Label Randomized Proof‐of‐Principle Pharmacokinetic Study [O] . Yong Yue, Dongzhou J. Liu -1

机译：通过比较4种持续释放原型制剂和标准对乙酰氨基酚制剂的药代动力学曲线选择12小时持续释放对乙酰氨基酚（对乙酰氨基酚）制剂：一项开放标签随机原理证明药代动力学研究
7. A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles [O] . Hyewon Chung, Howard Lee, HyeKyung Han, 2015

机译：两种伏立康唑制剂的药代动力学比较及CYP2C19多态性对其药代动力学谱的影响

A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles

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