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A Phase II Study of Methotrexate Etoposide Dexamethasone and Pegaspargase Sandwiched with Radiotherapy in the Treatment of Newly Diagnosed Stage IE to IIE Extranodal Natural-Killer/T-Cell Lymphoma Nasal-Type

机译：甲氨蝶呤依托泊苷地塞米松和Pegaspargase夹心放疗的II期研究用于治疗新诊断的IIE期至IIE期结外自然杀手/ T细胞淋巴瘤鼻型

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BackgroundA phase II study of methotrexate, etoposide, dexamethasone, and pegaspargase (MESA) sandwiched with radiotherapy for newly diagnosed, stage IE-IIE extranodal natural-killer/T-cell lymphoma, nasal-type (ENKTL) was conducted to explore its clinical efficacy and safety, as well as novel serum biomarkers upon anti-metabolic treatment.

机译：背景甲氨蝶呤，依托泊苷，地塞米松和培加斯加酶（MESA）联合放疗对新诊断的IE-IIE期结外自然杀伤性/ T细胞鼻型（ENKTL）淋巴瘤进行了II期研究，以探讨其临床疗效和安全性，以及抗代谢治疗后的新型血清生物标志物。

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期刊名称 EBioMedicine
作者
Peng-Peng Xu; Jie Xiong; Shu Cheng; Xia Zhao; Chao-Fu Wang; Gang Cai; Hui-Juan Zhong; Heng-Ye Huang; Jia-Yi Chen; Wei-Li Zhao;
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作者单位

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年(卷),期 2017(25),-1
年度 2017
页码 41–49
总页数 9
原文格式 PDF
正文语种
中图分类
关键词
Extranodal natural-killer/T-cell lymphoma nasal type; Asparaginase; Metabolomic profile; Prognosis;

机译：鼻外型自然杀伤性/ T细胞淋巴瘤;天冬酰胺酶;代谢组学概况预后;

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专利

1. A Phase II Study of Methotrexate, Etoposide, Dexamethasone and Pegaspargase Sandwiched with Radiotherapy in the Treatment of Newly Diagnosed, Stage IE to IIE Extranodal Natural-Killer/T-Cell Lymphoma, Nasal-Type [J] . Peng-Peng Xu, Jie Xiong, Shu Cheng, EBioMedicine . 2017,第4期

机译：甲氨蝶呤，依托泊苷，地塞米松和Pegaspargase夹心放疗的II期研究，用于治疗新诊断的IE到IIE结外型自然杀手/ T细胞淋巴瘤（鼻型）
2. Effectiveness of pegaspargase, gemcitabine, and oxaliplatin (P-GEMOX) chemotherapy combined with radiotherapy in newly diagnosed, stage IE to IIE, nasal-type, extranodal natural killer/T-cell lymphoma [J] . Wen Wei, Ping Wu, Li Li, Hematology . 2017,第6期

机译：pegaspargase，吉西他滨和奥沙利铂（P-GEMOX）化疗联合放疗在新诊断的IE至IIE期，鼻型结外自然杀伤/ T细胞淋巴瘤中的有效性
3. Effectiveness of pegaspargase, gemcitabine, and oxaliplatin (P-GEMOX) chemotherapy combined with radiotherapy in newly diagnosed, stage IE to IIE, nasal-type, extranodal natural killer/T-cell lymphoma [J] . Wei Wen, Wu Ping, Li Li, Hematology. . 2017,第6期

机译：Pegaspargase，Gemcitabine和Oxaliplatin（P-Gemox）化疗的有效性与新诊断，阶段，鼻型，外侧天然杀伤/ T细胞淋巴瘤联合放射治疗
4. RISK-ADAPTED INTRAVENOUS MELPHALAN WITH ADJUVANT THALIDOMIDE AND DEXAMETHASONE FOR NEWLY DIAGNOSED UNTREATED PATIENTS WITH SYSTEMIC AL AMYLOIDOSIS: INTERIM REPORT OF A PHASE II TRIAL [C] . RL Comenzo, P Zhou, L Reich, International Symposium on Amyloidosis . 2005

机译：风险适应的静脉内莫尔甘蔗用佐剂沙利度胺和地塞米松，用于新诊断的未经治疗的全身淀粉样蛋白症患者：II期试验的中期报告
5. Safety and Efficacy of the Immunomodulatory Drug (IMiD) Lenalidomide in Patients with Lymphoma: Development of RU051417I - Phase I/II Open-Label Study of R-ICE (Rituximab-Ifosfamide-Carboplatin-Etoposide) with Lenalidomide [R2-ICE] in Patients with First-Relapse/Primary Refractory Diffuse Large B-Cell Lymphoma (DLBCL). [D] . Kasi, Pashtoon Murtaza. 2018

机译：免疫调节药物来那度胺在淋巴瘤患者中的安全性和有效性：RU051417I-R-ICE（利妥昔单抗-异环磷酰胺-卡铂-依托泊苷）与来那度胺[R2-ICE]的I / II期开放标签研究的进展初次复发/原发性难治性弥漫性大B细胞淋巴瘤（DLBCL）。
6. A phase II prospective study of the Sandwich protocol L-asparaginase cisplatin dexamethasone and etoposide chemotherapy combined with concurrent radiation and cisplatin in newly diagnosed I/II stage nasal type extranodal natural killer/T-cell lymphoma [O] . Ming Jiang, Li Zhang, Li Xie, 2017

机译：在新诊断的I / II期鼻腔类型结外自然杀伤/ T细胞淋巴瘤中对三明治方案L-天冬酰胺酶顺铂地塞米松和依托泊苷化学疗法同时进行放疗和顺铂联合进行的II期前瞻性研究
7. A Phase II Study of Methotrexate, Etoposide, Dexamethasone and Pegaspargase Sandwiched with Radiotherapy in the Treatment of Newly Diagnosed, Stage IE to IIE Extranodal Natural-Killer/T-Cell Lymphoma, Nasal-Type [O] . Peng-Peng Xu, Jie Xiong, Shu Cheng, 2017

机译：甲氨蝶呤，依托咪酯，地塞米松和pegaspargase夹心放射治疗新诊断的IE-IIE结外自然杀伤/ T细胞淋巴瘤，鼻型的II期研究

A Phase II Study of Methotrexate Etoposide Dexamethasone and Pegaspargase Sandwiched with Radiotherapy in the Treatment of Newly Diagnosed Stage IE to IIE Extranodal Natural-Killer/T-Cell Lymphoma Nasal-Type

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