People living with HIV infection (PWH) disclose that cannabis is an effective strategy for alleviating symptoms associated with HIV disease. However, some medical providers feel ill-informed to engage in evidence-based conversations. HIV leads to alterations in the gut microbiome, gut–brain axis signaling, and chronic inflammation. The endocannabinoid system regulates homeostasis of multiple organ systems. When deficient, dysregulation of the gut–brain axis can result in chronic inflammation and neuroinflammation. Cannabis along with the naturally occurring endocannabinoids has antioxidant and anti-inflammatory properties that can support healing and restoration as an adjunctive therapy. The purpose of this literature review is to report the physiologic mechanisms that occur in the pathology of HIV and discuss potential benefits of cannabinoids in supporting health and reducing the negative effects of comorbidities in PWH.
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机译：HIV 感染者 （PWH） 透露，大麻是缓解与 HIV 疾病相关的症状的有效策略。然而，一些医疗服务提供者觉得不知情，无法进行循证对话。HIV 导致肠道微生物组、肠脑轴信号传导和慢性炎症的改变。内源性大麻素系统调节多个器官系统的稳态。缺乏时，肠-脑轴失调会导致慢性炎症和神经炎症。大麻与天然存在的内源性大麻素一起具有抗氧化和抗炎特性，可以作为辅助疗法支持愈合和恢复。本文献综述的目的是报告 HIV 病理学中出现的生理机制，并讨论大麻素在支持健康和减少 PWH 合并症的负面影响方面的潜在益处。
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