Intrathecal chemotherapy is often administered for prophylaxis and treatment of central nervous system involvement in hematological malignancies. However, it may rarely cause neurotoxicity as a side effect.We herein report a 74-year-old woman with diffuse large B-cell lymphoma including a spinal lesion. She received systemic and intrathecal chemotherapy. After five doses of intrathecal chemotherapy, she developed intrathecal chemotherapy-induced myelopathy. Intrathecal treatment was discontinued, and she was administered vitamin B12 and folic acid, along with steroid pulses. However, her symptoms did not improve. Intrathecal chemotherapy-induced myelopathy is rare, but may be irreversible; therefore, clinicians should be aware of this potential complication.
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机译：鞘内化疗通常用于预防和治疗血液系统恶性肿瘤中的中枢神经系统受累。然而，它可能很少引起神经毒性作为副作用。我们在此报告一名 74 岁的女性，患有弥漫性大 B 细胞淋巴瘤，包括脊髓病变。她接受了全身和鞘内化疗。在接受了 5 剂鞘内化疗后，她患上了鞘内化疗引起的脊髓病。停止鞘内治疗，她接受了维生素 B12 和叶酸以及类固醇脉冲。然而，她的症状并没有改善。鞘内化疗诱导的脊髓病很少见，但可能是不可逆的;因此，临床医生应了解这种潜在的并发症。
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