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Seasonal Clock Changes Are Underappreciated Health Risks—Also in IBD?

机译:季节性时钟变化是否对健康风险造成了低估—在IBD中也是如此?

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摘要

Today, daylight saving time is observed in nearly 80 countries around the world, including the European Union, the USA, Canada, and Russia. The benefits of daylight saving time in energy management have been questioned since it was first introduced during World War I and the latest research has led to varying results. Meanwhile, adverse effects of seasonal time shifts on human biology have been postulated and the European Union is planning to abandon the biannual clock change completely. Medical studies have revealed a correlation of seasonal time shifts with increased incidences of several diseases including stroke, myocardial infarction, and unipolar depressive episodes. Moreover, studies in mice have provided convincing evidence, that circadian rhythm disruption may be involved in the pathogenesis of inflammatory bowel diseases, mainly by disturbing the intestinal barrier integrity. Here, we present previously unpublished data from a large German cohort indicating a correlation of seasonal clock changes and medical leaves due to ulcerative colitis and Crohn's disease. Furthermore, we discuss the health risks of clock changes and the current attempts on reforming daylight saving time from a medical perspective.
机译:如今,在包括欧盟,美国,加拿大和俄罗斯在内的全球将近80个国家/地区都可以看到夏令时。自从第一次世界大战期间首次采用夏令时以来,它在能源管理中的好处就受到了质疑,最新的研究得出了不同的结果。同时,已经假定了季节性时移对人类生物学的不利影响,欧盟计划完全放弃每两年一次的时钟变化。医学研究表明,季节性时移与多种疾病(包括中风,心肌梗塞和单相抑郁发作)的发生率增加相关。此外,在小鼠中的研究提供了令人信服的证据,即昼夜节律的破坏可能与炎症性肠病的发病机理有关,主要是通过干扰肠道屏障的完整性。在这里,我们呈现了先前来自大型德国队列的未发表数据,这些数据表明由于溃疡性结肠炎和克罗恩氏病而引起的季节性时钟变化和医学休假的相关性。此外,我们从医学的角度讨论了时钟变化的健康风险以及当前尝试改革夏时制的尝试。

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