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Subcutaneous leiomyosarcoma in a cynomolgus macaque (Macaca fascicularis)

机译:食蟹猴 (Macaca fascicularis) 的皮下平滑肌肉瘤

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摘要

Leiomyosarcoma, a malignant tumour originating from smooth muscle cells, has rarely been documented in non‐human primates. In this case study, a 7‐year‐old female cynomolgus macaque (Macaca fascicularis) presented with a rapidly growing mass overlying the left elbow joint. Radiographs indicated the presence of a soft tissue neoplasm without any associated bone involvement. The mass was surgically resected. Histological and immunohistochemical analyses revealed spindle‐shaped cells with eosinophilic cytoplasm that resembled smooth muscle cells, exhibiting positive immunoreactions for vimentin, desmin and smooth muscle actin and a negative reaction for pan‐cytokeratin. This is the first reported case of subcutaneous leiomyosarcoma in a cynomolgus macaque and provides important insights into the incidence and characteristics of this condition in this species.
机译:平滑肌肉瘤是一种起源于平滑肌细胞的恶性肿瘤,在非人灵长类动物中很少被记录。在本案例研究中,一只 7 岁的雌性食蟹猴 (Macaca fascicularis) 在左肘关节上出现一个迅速生长的肿块。X 线片显示存在软组织肿瘤,但没有任何相关的骨骼受累。肿块被手术切除。组织学和免疫组织化学分析显示梭形细胞,具有类似于平滑肌细胞的嗜酸性粒细胞质,表现出波形蛋白、结蛋白和平滑肌肌动蛋白的阳性免疫反应,以及全细胞角蛋白的阴性反应。这是食蟹猴猕猴皮下平滑肌肉瘤的首例报道,并为该物种中这种情况的发病率和特征提供了重要见解。

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