Serine/arginine splicing factor 10 (SRSF10) is a member of the family of mammalian splicing regulators known as SR proteins. Like several of its SR siblings, the SRSF10 protein is composed of an RNA binding domain (RRM) and of arginine and serine-rich auxiliary domains (RS) that guide interactions with other proteins. The phosphorylation status of SRSF10 is of paramount importance for its activity and is subjected to changes during mitosis, heat-shock, and DNA damage. SRSF10 overexpression has functional consequences in a growing list of cancers. By controlling the alternative splicing of specific transcripts, SRSF10 has also been implicated in glucose, fat, and cholesterol metabolism, in the development of the embryonic heart, and in neurological processes. SRSF10 is also important for the proper expression and processing of HIV-1 and other viral transcripts. We discuss how SRSF10 could become a potentially appealing therapeutic target to combat cancer and viral infections.
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机译：丝氨酸/精氨酸剪接因子 10 （SRSF10） 是称为 SR 蛋白的哺乳动物剪接调节因子家族的成员。与其几个 SR 兄弟姐妹一样，SRSF10 蛋白由 RNA 结合结构域 （RRM） 以及指导与其他蛋白质相互作用的富含精氨酸和丝氨酸的辅助结构域 （RS） 组成。SRSF10 的磷酸化状态对其活性至关重要，并且在有丝分裂、热休克和 DNA 损伤期间会发生变化。SRSF10 过表达在越来越多的癌症中具有功能影响。通过控制特异性转录本的选择性剪接，SRSF10 还与葡萄糖、脂肪和胆固醇代谢、胚胎心脏的发育和神经过程有关。SRSF10 对于 HIV-1 和其他病毒转录物的正确表达和加工也很重要。我们讨论了 SRSF10 如何成为对抗癌症和病毒感染的潜在有吸引力的治疗靶点。
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