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You Don’t Muck with MYC

机译:你不喜欢MYC

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摘要

MYC homeostasis is critical for major cellular and organismal processes. The physiological and pathologic patterns of c-myc transcription are programmed by a large number of cis-elements and transfactors (RNAs and proteins). These elements and factors receive inputs from a multitude of intracellular and extracellular pathways. Because c-myc regulation has customarily been dissected element by element and factor by factor, it has been difficult to appreciate how the c-myc promoter and regulatory sequences operate as a system. A full accounting of the regulation of c-myc transcription will require an understanding of the dynamic interplay of these factors and elements with one another, with chromatin, and with the changes in DNA structure and topology that are inevitably coupled with gene activity.
机译:MYC动态平衡对于主要的细胞和生物过程至关重要。 c-myc转录的生理和病理模式是由大量的顺式元件和转座因子(RNA和蛋白质)编程的。这些元素和因素从众多的细胞内和细胞外途径获得输入。因为通常习惯性地逐个要素地分解c-myc调控,所以很难理解c-myc启动子和调控序列如何作为系统运行。要全面了解c-myc转录调控,需要了解这些因素和元件彼此之间的动态相互作用,以及染色质,以及不可避免地与基因活性相关的DNA结构和拓扑变化。

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