The UCP2 -866G/A Ala55Val and UCP3 -55C/Tpolymorphisms are associated with premature coronary artery disease andcardiovascular risk factors in Mexican population

摘要

We examined the role of UCP gene polymorphisms as susceptibility markers for premature coronary artery disease (pCAD). The UCP2 Ala55Val (C/T rs660339), UCP2 -866G/A (rs659366), and UCP3 -55C/T (rs1800849) polymorphisms were genotyped in 948 patients with pCAD, and 763 controls. The distribution of the UCP2 A55V (C/T rs660339) and UCP3 -55 (rs1800849) was similar in patients and controls. However, under a recessive model, the UCP2 -866 (rs659366) A allele was associated with increased risk of developing pCAD (OR = 1.43, Pc = 0.003). On the other hand, patients with pCAD and UCP2 A55V (rs660339) TT showed high levels of visceral abdominal fat (VAF) (Pc = 0.002), low levels of subcutaneous abdominal fat (SAF) (Pc = 0.001) and high VAT/SAT ratio (Pc < 0.001). Also, patients with UCP2 -866 (rs659366) AA showed increased levels of VAF (Pc = 0.003), low levels of SAF (Pc =0.001) and a high VAT/SAT ratio (Pc = 0.002), whereas patientswith the UCP3 -55 (rs1800849) TT presentedhigh levels of VAF (Pc = 0.002). The results suggest theassociation of the UCP2 -866 (rs659366) polymorphism with riskof developing pCAD. Some polymorphisms were associated with abdominal fat levelsand cardiovascular risk factors.