Evaluation of the VP22 protein for enhancement of a DNA vaccine against anthrax

机译：评估VP22蛋白增强抗炭疽DNA疫苗的能力

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BackgroundPreviously, antigens expressed from DNA vaccines have been fused to the VP22 protein from Herpes Simplex Virus type I in order to improve efficacy. However, the immune enhancing mechanism of VP22 is poorly understood and initial suggestions that VP22 can mediate intercellular spread have been questioned. Despite this, fusion of VP22 to antigens expressed from DNA vaccines has improved immune responses, particularly to non-secreted antigens.

机译：背景技术以前，DNA疫苗表达的抗原已经与I型单纯疱疹病毒的VP22蛋白融合，以提高功效。然而，对VP22的免疫增强机制了解甚少，并且对VP22可以介导细胞间扩散的初步建议提出了质疑。尽管如此，VP22与DNA疫苗表达的抗原的融合仍改善了免疫反应，特别是对非分泌抗原的免疫反应。

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期刊名称 Genetic Vaccines and Therapy
作者
Stuart D Perkins; Helen C Flick-Smith; Helen S Garmory; Angela E Essex-Lopresti; Freda K Stevenson; Robert J Phillpotts;
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年(卷),期 2005(3),-1
年度 2005
页码 3
总页数 9
原文格式 PDF
正文语种
中图分类生化遗传学;生化药理学;
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专利

1. Evaluation of the VP22 protein for enhancement of a DNA vaccine against anthrax [J] . Stuart D Perkins, Helen C Flick-Smith, Helen S Garmory, Genetic Vaccines and Therapy . 2005,第1期

机译：评估VP22蛋白增强抗炭疽DNA疫苗的能力
2. Evaluation of the VP22 gene adjuvant for enhancement of DNA vaccine against somatostatin in mice. [J] . Han L., Liang A. X., Zhang J., Animal . 2008,第11期

机译：VP22基因佐剂增强小鼠抗生长抑素DNA疫苗的评价。
3. Evaluation of the VP22 gene adjuvant for enhancement of DNA vaccine against somatostatin in mice [J] . A. X. Liang, G. H. Hua, H. R. Wang, Animal . 2008,第11期

机译：VP22基因佐剂增强小鼠生长抑素DNA疫苗的评价
4. DNA Vaccines Co-expressing Containing Hsp70 and GP5/M Protein of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Display Enhanced Immunogenicity [C] . Zuo Lan, Yan Qi-Gui, Lei Yan, International Conference on Mechanical Engineering and Intelligent Systems . 2012

机译：DNA疫苗共同含有HSP70和猪生殖和呼吸综合征病毒（PRRSV）的GP5 / M蛋白显示出增强的免疫原性
5. Design, synthesis, and evaluation of synthetic particulate delivery systems in DNA and protein vaccine delivery. [D] . Kasturi, Sudhir Pai. 2006

机译：设计，合成和评估DNA和蛋白质疫苗输送中的合成颗粒输送系统。
6. Exploiting the activity of VP22 to enhance the delivery of antigens encoded by DNA vaccine plasmids [O] . Vidia Roopchand, Dorys Garcia-Hand, Kangjian Wu, 2006

机译：利用VP22的活性增强DNA疫苗质粒编码抗原的传递
7. Evaluation of the VP22 protein for enhancement of a DNA vaccine against anthrax [O] . Stevenson Freda K, Essex-Lopresti Angela E, Garmory Helen S, 2005

机译：评估VP22蛋白增强抗炭疽DNA疫苗的能力
8. Cationic Lipid-Formulated Plasmid DNA Vaccine Confers Sustained Antibody-Mediated Protection Against Aerosolized Anthrax Spores [R] . Hermanson, G. , Whitlow, V. , Parker, S. , 2004

机译：阳离子脂质配方质粒DNa疫苗可提供持续的抗体介导保护，防止气雾化炭疽孢子

Evaluation of the VP22 protein for enhancement of a DNA vaccine against anthrax

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