Systems biology-defined NF-κB regulons interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status

摘要

BackgroundAberrant activation of the nuclear factor kappaB (NF-κB) pathway has been previously implicated as a crucial signal promoting tumorigenesis. However, how NF-κB acts as a key regulatory node to modulate global gene expression, and contributes to the malignant heterogeneity of head and neck cancer, is not well understood.