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Effects of recombinant adenovirus-mediated expression of IL-2 and IL-12 in human B lymphoma cells on co-cultured PBMC

机译：重组腺病毒介导的人B淋巴瘤细胞中IL-2和IL-12表达对PBMC共培养的影响

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BackgroundModulation of the immune system by genetically modified lymphoma cell vaccines is of potential therapeutic value in the treatment of B cell lymphoma. However, the anti-tumor effect of any single immunogene transfer has so far been limited. Combination treatment of recombinant IL-2 and IL-12 has been reported to be synergistic for inducing anti-tumor responses in solid tumors but the potential of IL-2/IL-12 gene modified B cell lymphoma cells has not been explored yet.

机译：背景技术转基因淋巴瘤细胞疫苗对免疫系统的调节在治疗B细胞淋巴瘤方面具有潜在的治疗价值。但是，迄今为止，任何单一免疫基因转移的抗肿瘤作用都受到限制。已经报道重组IL-2和IL-12的联合治疗在实体瘤中诱导抗肿瘤应答是协同的，但是尚未探索IL-2 / IL-12基因修饰的B细胞淋巴瘤细胞的潜力。

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期刊名称 Genetic Vaccines and Therapy
作者
Oliver Ebert; Dorothee Wilbert; Peter Buttgereit; Carsten Ziske; Dimitri Flieger; Ingo GH Schmidt-Wolf;
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年(卷),期 2004(2),-1
年度 2004
页码 15
总页数 8
原文格式 PDF
正文语种
中图分类生化遗传学;生化药理学;
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专利

1. Effects of recombinant adenovirus-mediated expression of IL-2 and IL-12 in human B lymphoma cells on co-cultured PBMC [J] . Oliver Ebert, Dorothee Wilbert, Peter Buttgereit, Genetic Vaccines and Therapy . 2004,第1期

机译：重组腺病毒介导的人B淋巴瘤细胞IL-2和IL-12表达对PBMC共培养的影响
2. Age-associated decline in IL-2 and IL-12 induction of LAK cell activity of human PBMC samples. [J] . Kutza J, Murasko DM Mechanisms of Ageing and Development . 1996,第3期

机译：人PBMC样品的IL-2和IL-12诱导的LAK细胞活性的年龄相关下降。
3. IL-12 as well as IL-2 upregulates CCR5 expression on T cell receptor-triggered human CD4+ and CD8+ T cells. [J] . Yang YF, Tomura M, Iwasaki M, Journal of Clinical Immunology . 2001,第2期

机译：IL-12和IL-2上调T细胞受体触发的人CD4 +和CD8 + T细胞上CCR5的表达。
4. Immunologic Synergism with IL-2 and Effects of cCHMIs on mRNA Expression of IL-2 and IFN-γ in Chicken Peripheral T lymphocyte [C] . WANG Deyun, LI Xiangrui, XU Lixin, Academic Conference of Asian Society of Traditional Veterinary Medicine; 200610; Beijing(CN) . 2006

机译：IL-2的免疫协同作用及cCHMIs对鸡外周血T淋巴细胞IL-2和IFN-γmRNA表达的影响
5. Il-12 synergizes with Il-2 to induce lymphokine activated cytotoxicity and perforin and granzyme gene expression in fresh human NK cells [D] . DeBlaker-Hohe, D'Anna Faye 1995

机译：Il-12与Il-2协同作用，诱导新鲜人NK细胞中淋巴因子激活的细胞毒性以及穿孔素和颗粒酶基因表达
6. Effects of recombinant human growth hormone on protein malnutrition and IGF-1 and IL-2 gene expression levels in chronic nephrotic syndrome [O] . Guang Dai, Donghai Wang, Hua Dong -1

机译：重组人生长激素对慢性肾病综合征患者蛋白质营养不良及IGF-1和IL-2基因表达水平的影响
7. Effects of recombinant adenovirus-mediated expression of IL-2 and IL-12 in human B lymphoma cells on co-cultured PBMC [O] . Ziske Carsten, Buttgereit Peter, Wilbert Dorothee, 2004

机译：重组腺病毒介导的人B淋巴瘤细胞中IL-2和IL-12表达对PBMC共培养的影响

Effects of recombinant adenovirus-mediated expression of IL-2 and IL-12 in human B lymphoma cells on co-cultured PBMC

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