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美国卫生研究院文献>Genome Biology
>Species-specific shifts in centromere sequence composition are coincident with breakpoint reuse in karyotypically divergent lineages
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Species-specific shifts in centromere sequence composition are coincident with breakpoint reuse in karyotypically divergent lineages
BackgroundIt has been hypothesized that rapid divergence in centromere sequences accompanies rapid karyotypic change during speciation. However, the reuse of breakpoints coincident with centromeres in the evolution of divergent karyotypes poses a potential paradox. In distantly related species where the same centromere breakpoints are used in the independent derivation of karyotypes, centromere-specific sequences may undergo convergent evolution rather than rapid sequence divergence. To determine whether centromere sequence composition follows the phylogenetic history of species evolution or patterns of convergent breakpoint reuse through chromosome evolution, we examined the phylogenetic trajectory of centromere sequences within a group of karyotypically diverse mammals, macropodine marsupials (wallabies, wallaroos and kangaroos).
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