Merkel cell carcinoma (MCC) is a rare primary neuroendocrine carcinoma commonly found in older adults in areas of the skin that are susceptible to ultraviolet ray damage. The current study reports the case of a 79-year-old woman who presented to the Affiliated Hospital of Zunyi Medical University (Zunyi, China) with a painless lump in the lower eyelid of the left eye accompanied by photophobic tears for 4 months. Head computed tomography (CT) and magnetic resonance imaging (MRI) showed a space-occupying lesion ~2.8×2.4 cm in size outside the left orbital muscle cone, which was poorly demarcated from the surrounding normal tissues. Markedly intense and tortuous walking vascular shadows were observed within the tumor tissues. Fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG PET)/CT revealed increased 18F-FDG uptake in the corresponding lesions. Based on these imaging features, a malignant tumor was suspected. The patient subsequently underwent surgery. Postoperative pathology and immunohistochemistry revealed MCC. The clinical presentation of MCC is usually a painless soft-tissue nodule or mass that grows rapidly over a short period and is flesh-colored, bluish red or purple. A slightly hyperdense mass on CT, with equal T1-weighted and slightly longer T2-weighted MRI signals, and mild enhancement on contrast-enhanced scans, accompanied by significantly enhanced distorted vascular shadows and increased 18F-FDG uptake on PET/CT, are valuable in the diagnosis of eyelid MCC.
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