Gli1 downregulated in colorectal cancers inhibits proliferation of colon cancer cells involving Wnt signalling activation

摘要

BackgroundEarly events in the progression of 90% of sporadic colorectal cancers depend on constitutive activation of Wnt signalling. Recent data also indicate a close association between the Hedgehog (Hh) and Wnt pathways in colonic epithelial cell differentiation.