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Chronic Obstructive Pulmonary Disease Mortality and Hospitalization during the COVID-19 Pandemic Compared with before the Pandemic: A Systematic Review and Meta-Analysis

机译:与大流行前相比COVID-19 大流行期间的慢性阻塞性肺疾病死亡率和住院率:系统评价和荟萃分析

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摘要

This study aimed to assess the impact of the pandemic on hospitalization and mortality rates among patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). We conducted a systematic search across three medical databases for studies comparing the AECOPD mortality and hospitalization rates during the COVID-19 pandemic with those before the pandemic, up until December 2023. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Meta-analysis of Observational Studies in Epidemiology guidelines, we performed a meta-analysis with a random-effects model to pool odds ratios (ORs), 95% confidence intervals (CIs), and heterogeneity (I2). From 4689 records, 21 studies met our inclusion criteria. Our analysis revealed a significant increase in in-hospital mortality during the pandemic (pooled OR = 1.27, 95% CI = 1.17–1.39, I2 = 50%). Subgroup analysis highlighted a more pronounced mortality risk in single-center studies and smaller populations. Conversely, hospitalization rates for AECOPD significantly declined during the pandemic (pooled OR = 0.39, 95% CI = 0.18–0.85, I2 = 99%). The study demonstrates that during the COVID-19 pandemic, there was a substantial decrease in hospital admissions for AECOPD and an increase in in-hospital deaths. This shows that better healthcare plans and pandemic preparedness are needed to help people with chronic conditions.
机译:本研究旨在评估大流行对慢性阻塞性肺疾病急性加重 (AECOPD) 患者住院率和死亡率的影响。我们在三个医学数据库中进行了系统检索,以查找比较 COVID-19 大流行期间与大流行前(截至 2023 年 12 月)的 AECOPD 死亡率和住院率的研究。使用流行病学指南中系统综述和荟萃分析的首选报告项目以及观察性研究的荟萃分析,我们使用随机效应模型进行荟萃分析,以合并比值比 (ORs)、95% 置信区间 (CIs) 和异质性 (I2)。从 4689 条记录中,有 21 项研究符合我们的纳入标准。我们的分析显示,大流行期间院内死亡率显着增加 (汇总 OR = 1.27,95% CI = 1.17-1.39,I2 = 50%)。亚组分析强调,在单中心研究和较小人群中,死亡风险更为明显。相反,AECOPD 的住院率在大流行期间显着下降 (汇总 OR = 0.39,95% CI = 0.18-0.85,I2 = 99%)。该研究表明,在 COVID-19 大流行期间,AECOPD 的住院人数大幅减少,住院死亡人数增加。这表明需要更好的医疗保健计划和大流行病准备来帮助慢性病患者。

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