Background: Incidence of fungal rhinosinusitis has increased in recent few years. We investigated the differences in microbiological findings between patients with fungal and non-fungal rhinosinusitis by growing microbiological cultures from samples obtained from sinus surgery. Methods: Using the Chang Gung Research Database, we enrolled all chronic rhinosinusitis (CRS) patients who had ever undergone sinus surgery from 2001 to 2019 and had microbiological culture during sinus surgery. Enrolled patients were divided into fungal and non-fungal groups, based on fungal culture and surgical pathology. Results: A total of 898 patients were diagnosed with fungal rhinosinusitis and 2884 with non-fungal rhinosinusitis. The fungal group had a higher age distribution (56.9 ± 13.1 vs. 47.0 ± 14.9), a larger proportion of females (62.4% vs. 37.0%), more unilateral lesions (80.4% vs. 41.6%), a lower incidence of the need for revision surgery (3.6% vs. 6.0%, p = 0.004), and a higher proportion of Pseudomonas aeruginosa in the culture (14.3% vs. 4.6%, p < 0.001). Conclusions: This large-scale study showed that Pseudomonas aeruginosa are more commonly found in patients with fungal rhinosinusitis and in patients who needed revision surgery, suggesting that efforts aimed at eliminating Pseudomonas are needed in order to improve the disease outcomes of patients with fungal rhinosinusitis.
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机译：背景：近年来真菌性鼻-鼻窦炎的发病率有所增加。我们通过从鼻窦手术获得的样本中培养微生物培养物，调查了真菌性和非真菌性鼻鼻窦炎患者之间微生物学发现的差异。方法： 使用长庚研究数据库，我们招募了 2001 年至 2019 年接受过鼻窦手术并在鼻窦手术期间进行微生物培养的所有慢性鼻窦炎 （CRS） 患者。根据真菌培养和手术病理学，将入组患者分为真菌组和非真菌组。结果： 共有 898 例患者被诊断为真菌性鼻-鼻窦炎，2884 例被诊断为非真菌性鼻-鼻窦炎。真菌组具有较高的年龄分布 （56.9 ± 13.1 vs. 47.0 ± 14.9），女性比例较高 （62.4% vs. 37.0%），单侧病变较多 （80.4% vs. 41.6%），需要翻修手术的发生率较低 （3.6% vs. 6.0%，p = 0.004），培养物中铜绿假单胞菌的比例较高 （14.3% vs. 4.6%，p < 0.001）。结论： 这项大规模研究表明，铜绿假单胞菌更常见于真菌性鼻-鼻-鼻窦炎患者和需要翻修手术的患者，这表明需要努力消除假单胞菌，以改善真菌性鼻-鼻窦炎患者的疾病预后。
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