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HIVIS-DNA or HIVISopt-DNA priming followed by CMDR vaccinia-based boosts induce both humoral and cellular murine immune responses to HIV

机译：HIVIS-DNA或HIVISopt-DNA引发然后基于CMDR牛痘的增强诱导体液和细胞鼠对HIV的免疫反应

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BackgroundIn order to develop a more effective prophylactic HIV-1 vaccine it is important optimize the components, improve Envelope glycoprotein immunogenicity as well as to explore prime-boost immunization schedules. It is also valuable to include several HIV-1 subtype antigens representing the world-wide epidemic.

机译：背景为了开发更有效的预防性HIV-1疫苗，重要的是优化成分，提高包膜糖蛋白的免疫原性以及探索初免免疫方案。包括代表全球流行病的几种HIV-1亚型抗原也很有价值。

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期刊名称 Heliyon
作者
J Hinkula; S Petkov; K Ljungberg; D Hallengärd; A Bråve; M Isaguliants; T Falkeborn; S Sharma; V Liakina; M Robb; M Eller; B Moss; G Biberfeld; E Sandström; C Nilsson; K Markland; P Blomberg; B Wahren;
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年(卷),期 2017(3),6
年度 2017
页码 e00339
总页数 25
原文格式 PDF
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关键词
Immunology Infectious disease Vaccines Virology;

机译：免疫学;传染病;疫苗;病毒学;

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专利

1. Regulatory T cell abundance and activation status before and after priming with HIVIS-DNA and boosting with MVA-HIV/rgp140/GLA-AF may impact the magnitude of the vaccine-induced immune responses [J] . Chissumba Raquel Matavele, Luciano Abilio, Namalango Eduardo, Immunobiology: Zeitschrift fur Immunitatsforschung . 2018,第12期

机译：用HIVIS-DNA引发前后的调节性T细胞丰度和激活状态，并用MVA-HIV / RGP140 / GLA-AF促进促进疫苗诱导的免疫应答的大小
2. Broad and Potent Cellular and Humoral Immune Responses After a Second Late HIV-Modified Vaccinia Virus Ankara Vaccination in HIV-DNA-Primed and HIV-Modified Vaccinia Virus Ankara-Boosted Swedish Vaccinees [J] . Charlotta Nilsson, Karina Godoy-Ramirez, Bo Hejdeman, AIDS Research and Human Retroviruses . 2014,第3期

机译：在艾滋病毒-DNA灌注和艾滋病毒改性痘苗病毒Ankara-Boosted瑞典疫苗中，在第二次艾滋病毒改性的痘苗病病毒Ankara接种后的广泛和有效的细胞和体液免疫反应
3. Priming with rAAV encoding RBD of SARS-CoV S protein and boosting with RBD-specific peptides for T cell epitopes elevated humoral and cellular immune responses against SARS-CoV infection. [J] . Lanying Du, Guangyu Zhao, Yongping Lin, Vaccine . 2008,第13期

机译：用编码SARS-CoV S蛋白的RBD的rAAV引发和用针对T细胞表位的RBD特异性肽增强，可增强针对SARS-CoV感染的体液和细胞免疫应答。
4. Combination of Pathogen-mimicking Polymer Particles and an Injectable, Synthetic Immune-Priming Center (sIPC) Significantly Enhances Cellular and Protective Immunity in Murine Models of Cancer [C] . Pallab Pradhan, Eileen Dawson, Jardin Leleux, Society for Biomaterials annual meeting and exposition . 2013

机译：模仿病原体的聚合物颗粒和可注射的合成免疫刺激中心（sIPC）的组合可显着增强癌症小鼠模型的细胞和保护性免疫力。
5. Humoral and cellular immune responses in RNA viral infections: Immunogenicity of HIV-1, HCV and SARS-CoV candidate vaccines in animal models. [D] . Azizi, Ali. 2006

机译：RNA病毒感染中的体液和细胞免疫应答：HIV-1，HCV和SARS-CoV候选疫苗在动物模型中的免疫原性。
6. Broad and Potent Cellular and Humoral Immune Responses After a Second Late HIV-Modified Vaccinia Virus Ankara Vaccination in HIV-DNA-Primed and HIV-Modified Vaccinia Virus Ankara-Boosted Swedish Vaccinees [O] . Charlotta Nilsson, Karina Godoy-Ramirez, Bo Hejdeman, -1

机译：在以HIV DNA为主要成分和以HIV修饰的痘苗病毒的安卡拉免疫瑞典疫苗中进行第二次晚期HIV修饰的痘苗病毒安卡拉疫苗接种后广泛而有效的细胞和体液免疫反应
7. HIVIS-DNA or HIVISopt-DNA priming followed by CMDR vaccinia-based boosts induce both humoral and cellular murine immune responses to HIV. [O] . Hinkula, Jorma, Petkov, S, Ljungberg, K, 2017

机译：先进行HIVIS-DNA或HIVISopt-DNA引发，然后进行基于CMDR牛痘的加强免疫，诱导体液和细胞鼠对HIV的免疫反应。

HIVIS-DNA or HIVISopt-DNA priming followed by CMDR vaccinia-based boosts induce both humoral and cellular murine immune responses to HIV

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