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Statins decrease vascular epithelial growth factor expression via down-regulation of receptor for advanced glycation end-products

机译：他汀类药物通过下调晚期糖基化终产物受体的表达而降低血管上皮生长因子的表达

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摘要

AimsStatins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, possess pleiotropic effects that have been extended to modulation of various cellular behaviors. This study aimed to examine whether statins modulate vascular endothelial growth factor A (VEGF-A) expression in human retinal pigment epithelium (RPE) cells.

机译：AimsStatins是3-羟基-3-甲基戊二酰辅酶A还原酶的抑制剂，具有多效性作用，该作用已扩展到各种细胞行为的调节。这项研究旨在检查他汀类药物是否能调节人视网膜色素上皮细胞（RPE）细胞中的血管内皮生长因子A（VEGF-A）表达。

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期刊名称 Heliyon
作者
Hiroki Tsujinaka; Asako Itaya-Hironaka; Akiyo Yamauchi; Sumiyo Sakuramoto-Tsuchida; Ryogo Shobatake; Mai Makino; Naonori Masuda; Hiromasa Hirai; Shin Takasawa; Nahoko Ogata;
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年(卷),期 2017(3),9
年度 2017
页码 e00401
总页数 18
原文格式 PDF
正文语种
中图分类
关键词
Biological sciences Ophthalmology Biochemistry Cell biology;

机译：生物科学;眼科学;生物化学;细胞生物学;

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专利

1. Statins decreases vascular epithelial growth factor (VEGF) expression in experimental age-related macular degradation (AMD) model by down-regulation of receptor for advanced glycation end-products (RAGE) [J] . Tsujinaka Hiroki, Itaya-Hironaka Asako, Yamauchi Akiyo, Investigative ophthalmology & visual science . 2017,第8期

机译：他汀类药物通过对高级糖糖末端产物（RAGE）的受体的下调来降低实验性年龄相关性黄斑（AMD）模型中的实验年龄相关黄斑（AMD）模型中的血管上皮生长因子（VEGF）表达。
2. Statins decreases vascular epithelial growth factor (VEGF) expression in experimental age-related macular degradation (AMD) model by down-regulation of receptor for advanced glycation end-products (RAGE) [J] . Tsujinaka Hiroki, Itaya-Hironaka Asako, Yamauchi Akiyo, Investigative ophthalmology & visual science . 2017,第8期

机译：他汀类药物通过对高级糖糖末端产物（RAGE）的受体的下调来降低实验性年龄相关性黄斑（AMD）模型中的实验年龄相关黄斑（AMD）模型中的血管上皮生长因子（VEGF）表达。
3. Intra-coronary administration of soluble receptor for advanced glycation end-products attenuates cardiac remodeling with decreased myocardial transforming growth factor-pl expression and fibrosis in minipigs with ischemia-reperfusion injury [J] . LU Lin, ZHANG Qi, XU Yan, 中华医学杂志：英文版 . 2010,第005期

机译：冠状动脉内施用可溶性受体以使晚期糖基化终产物减轻缺血再灌注损伤的小猪的心肌重塑，降低其心肌转化生长因子-pl的表达和纤维化
4. ANTIBODY-FREE LC-MS METHODS FOR LOW TO SUB NG/ML QUANTIFICATION OF THE SOLUBLE RECEPTOR OF ADVANCED GLYCATION END-PRODUCTS (sRAGE) IN SERUM [C] . Frank Klont, Simon D. Pouwels, Marrit Hadderingh, International Mass Spectrometry Conference . 2018

机译：用于低至亚Ng / ml定量的无抗体的LC-MS方法，血清中晚期糖糖末端产物（SRAGE）的可溶性受体的定量
5. Receptor for advanced glycation end-products: Expression and signaling. [D] . Gefter, Julia V. 2009

机译：晚期糖基化终产物的受体：表达和信号传导。
6. Short-term glutamine supplementation decreases lung inflammation and the receptor for advanced glycation end-products expression in direct acute lung injury in mice [O] . Yin-Ching Chuang, Huey-Mei Shaw, Chi-Chung Chen, 2014

机译：短期补充谷氨酰胺可减轻小鼠直接急性肺损伤中的肺部炎症和晚期糖基化终产物表达的受体
7. Statins decrease vascular epithelial growth factor expression via down-regulation of receptor for advanced glycation end-products [O] . Hiroki Tsujinaka, Asako Itaya-Hironaka, Akiyo Yamauchi, 2017

机译：他汀类药物通过下调晚期糖基化终产物的受体来降低血管上皮生长因子的表达

Statins decrease vascular epithelial growth factor expression via down-regulation of receptor for advanced glycation end-products

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