Effect on the expression of drd2 and drd3 after neonatal lesion in the lymphocytes nucleus accumbens hippocampus and prefrontal cortex: comparative analysis between juvenile and adult Wistar rats

摘要

BackgroundNeonatal lesion in the ventral hippocampus (NLVH) is a validated animal model to study schizophrenia from a neurodevelopmental perspective. This animal model is also used to investigate how neonatal lesions may alter the genetic expression of dopaminergic receptors. The present study compares mRNA expression levels of dopamine receptors (drd2 and drd3) in lymphocytes and brain of NLVH animals at two different age stages: young and adult.