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Comprehensive analysis of clinicopathological profiles in adenosquamous carcinoma of the lung

机译:肺腺鳞癌临床病理特征的综合分析

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摘要

Objectives: Adenosquamous carcinoma (ASC), an uncommon subtype within non-small cell lung cancer (NSCLC), manifests distinctive traits of aggressiveness, embodying a fusion of both adenocarcinoma (AC) and squamous cell carcinoma (SCC) components. The clinicopathological characteristics of distinct subtypes of ASC remain unclear. Methods: This retrospective study included 226 patients diagnosed with lung ASC who consecutively underwent surgical resection at Shanghai Pulmonary Hospital, Tongji University, between January 2015 and March 2021. Data regarding the clinical features and pathological features were collected. Results: Out of this study cohort, 125 patients exhibited AC-predominant ASC, while 81 had SCC-predominant ASC. No significant differences were observed between the two subgroups in terms of age, gender, smoking history, primary site, and T, N classification. AC-Predominant ASC displayed a higher susceptibility to genetic alterations compared to SCC-Predominant ASC (P=0.02). Additionally, we showed that irrespective of the predominant pathological subtype in ASC, when lymph node metastasis occurred, the lymph node biopsies were more likely to exhibit AC, and a chi-square test confirmed that the primary predominant pathological subtype was not associated with the lymph node metastasis subtype. Conclusions: In conclusion, we describe an overview of ASC in the Chinese population, and upon stratifying into predominant pathological subgroups, we observed a higher frequency of driver gene mutations in AC-predominant ASC. We found that the AC component in ASC has a higher propensity for lymph node metastasis. These findings may suggest the predominant role of the AC component within the context of ASC.
机译:目的:腺鳞癌 (ASC) 是非小细胞肺癌 (NSCLC) 中的一种罕见亚型,表现出独特的侵袭性特征,体现了腺癌 (AC) 和鳞状细胞癌 (SCC) 成分的融合。ASC 不同亚型的临床病理特征仍不清楚。方法: 本回顾性研究纳入了 2015年1月至 2021年3月在同济大学上海肺科医院连续接受手术切除的 226 例肺 ASC 患者。收集有关临床特征和病理特征的数据。结果: 在该研究队列中,125 例患者表现出以 AC 为主的 ASC,而 81 例为 SCC 为主的 ASC。两个亚组在年龄、性别、吸烟史、原发部位和 T、N 分类方面未观察到显著差异。与 SCC 主导的 ASC 相比,AC-Predominant ASC 表现出更高的遗传改变易感性 (P=0.02)。此外,我们表明,无论 ASC 中的主要病理亚型如何,当淋巴结转移发生时,淋巴结活检更可能显示 AC,并且卡方检验证实主要病理亚型与淋巴结转移亚型无关。结论: 总之,我们描述了中国人群中 ASC 的概述,在分层为主要病理亚组后,我们观察到 AC 为主的 ASC 中驱动基因突变的频率较高。我们发现 ASC 中的 AC 成分具有更高的淋巴结转移倾向。这些发现可能表明 AC 成分在 ASC 背景下的主要作用。

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