Effect of recombinant human basic fibroblast growth factor combined with local application of insulin on pain and healing in diabetic patients with deep II degree burns

摘要

Objective: To investigate the efficacy of recombinant human basic fibroblast growth factor (rh-bFGF) combined with local application of insulin (INS) in diabetic patients with deep II degree burns, and to analyze the changes in pain and healing. Methods: Seventy-eight diabetic patients with deep II degree burns treated in our hospital were divided into the observation group (n=39) for combination therapy of rh-bFGF and local INS, and the control group (n=39) for rh-bFGF alone. The two groups were compared regarding treatment effect, wound healing time, pain degree (Visual Analogue Scale, VAS), wound exudate rate, vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α), as well as adverse reactions. Results: Compared with the control group, the total clinical effective rate was evidently higher in the observation group (P<0.05). The wound healing time was shorter and the VAS score was lower in the observation group as compared to the control group (both P<0.05). The observation group showed significantly lower wound exudate rate and higher HIF-1α and VEGF protein levels in wound tissue than the control group (all P<0.05). No adverse reactions such as abnormalities in blood routine and hepatorenal function were observed in the two groups during treatment. Conclusions: rh-bFGF combined with local application of INS is markedly effective in diabetic patients with deep II degree burns. It can relieve pain and shorten healing time, with low wound exudate rate and high safety profile.