Over the last decade, stem cell-based regenerative medicine has progressed to clinical testing and therapeutic applications. The applications range from infusions of autologous and allogeneic stem cells to stem cell-derived products. Adult stem cells from adipose tissue (ASCs) show significant promise in treating autoimmune and neurodegenerative diseases, vascular and metabolic diseases, bone and cartilage regeneration and wound defects. The regenerative capabilities of ASCs in vivo are primarily orchestrated by their secretome of paracrine factors and cell-matrix interactions. More recent developments are focused on creating more complex structures such as 3D organoids, tissue elements and eventually fully functional tissues and organs to replace or repair diseased or damaged tissues. The current and future applications for ASCs in regenerative medicine are discussed here.
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机译：在过去十年中，基于干细胞的再生医学已发展到临床测试和治疗应用。应用范围从自体和同种异体干细胞的输注到干细胞衍生产品。来自脂肪组织 （ASC） 的成体干细胞在治疗自身免疫和神经退行性疾病、血管和代谢疾病、骨骼和软骨再生以及伤口缺损方面显示出巨大的前景。ASC 在体内的再生能力主要由其旁分泌因子分泌组和细胞-基质相互作用协调。最近的发展集中在创建更复杂的结构，例如 3D 类器官、组织元素，并最终形成功能齐全的组织和器官，以替换或修复患病或受损的组织。本文讨论了 ASC 在再生医学中的当前和未来应用。
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