Chitosonic® Acid as a Novel Cosmetic Ingredient: Evaluation of its Antimicrobial Antioxidant and Hydration Activities

摘要

Chitosonic^® Acid, carboxymethyl hexanoyl chitosan, is a novel chitosan material that has recently been accepted by the Personal Care Products Council as a new cosmetic ingredient with the INCI (International Nomenclature of Cosmetic Ingredients) name Carboxymethyl Caprooyl Chitosan. In this study, we analyze several important cosmetic characteristics of Chitosonic^® Acid. Our results demonstrate that Chitosonic^® Acid is a water-soluble chitosan derivative with a high HLB value. Chitosonic^® Acid can form a nano-network structure when its concentration is higher than 0.5% and can self-assemble into a nanosphere structure when its concentration is lower than 0.2%. Chitosonic^® Acid has potent antimicrobial activities against gram-positive bacteria, gram-negative bacteria and fungus. Chitosonic^® Acid also has moderate DPPH radical scavenging activity. Additionally, Chitosonic^® Acid exhibits good hydration activity for absorbing and retaining water molecules with its hydrophilic groups. From a safety point of view, Chitosonic^® Acid has no cytotoxicity to L-929 cells if its concentration is less than 0.5%. Moreover, Chitosonic^® Acid has good compatibilities with various normal cosmetic ingredients. Therefore, we propose that Chitosonic^® Acid has the potential to be a widely used ingredient in various types of cosmetic products.