Study on the association between IL-1β IL-8 and IL-10 gene polymorphisms and risk of coronary artery disease

摘要

We aimed to evaluate the role of genetic polymorphisms in IL-1β, IL-8 and IL-10 in the risk of coronary artery disease (CAD). We identified 325 patients with CAD and 342 control subjects without CAD between January 2013 and December 2014. Genotyping of IL-1β +3954 C/T, IL-1β -511 C/T, IL-8-251T/A, IL-10-1082A/G and IL-10-819C/T was performed in a 384-well plate format on the Sequenom MassARRAY platform (Sequenom, San Diego, USA). By Multivariate logistic regression analysis, the GG and AG+GG genotypes of IL-10-1082A/G were significantly associated with an increased risk of CAD. The ORs (95% CI) for GG and AG+GG genotypes were 2.12 (1.32-3.43) and 1.56 (1.14-2.14), respectively. Patients carrying the AG+GG genotype of IL-10-1082A/G was associated with an increased risk of CAD in those with hypertension, diabetes mellitus and smokers, and the ORs (95% CI) were 1.41 (0.93-2.14), 7.13 (2.28-23.56) and 2.12 (1.17-3.89), respectively. Our study found that IL-10-1082A/G polymorphism is associated with an increased risk of CAD, especially in hypertension, diabetes mellitus and smokers.