产妇宫内感染对早产儿IL-1β、IL-6、IL-8、IL-10和TNF-α影响情况研究

摘要

Objectives:To investigate the effect of intrauterine infection on IL-1,IL-6,IL-8,IL-10 and TNF-alpha in premature infants.Methods:Retrospective analysis of the clinical data of preterm infants with intrauterine infection in our hospital from August 2015 to October 2016 was done.Preterm infants without intrauterine infection in our hospital in the same period were selected as control group.The serum levels of inflammatory cytokines,NIHSS score,renal function,myocardial enzymes and the general condition of two groups were observed.Results:The levels of IL-1,IL-6,IL-8,IL-10 and TNF-alpha in study group were significantly higher than these in control group (t =7.044,12.208,7.289,20.185,5.421,P ＜ 0.001).The SpO2 and PaO2 in study group were lower than those in control group (t =-6.353,-35.142,P ＜ 0.001).PaCO2 level in study group was higher than that of control group (t =35.720,P ＜0.001);The NIHSS score in study group was higher than that in control group (t =50.424,P ＜0.001),and the Apgar score of 1min and 5min in study group was lower than that of control group (t =-3.475,-4.398,P ＜ 0.001);The levels of urea nitrogen,creatinine and CK-MB in study group were higher than these in control group (t =49.014,11.611,16.458,P ＜ 0.001);Pearson correlation analysis showed that the levels of serum IL-1,IL-6,IL-8,IL-10 and TNF-alpha were positively correlated with NIHSS score,renal function and myocardial enzyme level,and negatively correlated with Apgar score.Conclusion:The levels of IL-1,IL-6,IL-8,IL-10 and TNF-alpha are higher in preterm infants with intrauterine infection,which are closely related to the NIHSS score,renal function and myocardial enzymes.%目的:探讨产妇宫内感染对早产儿IL-1β、IL-6、IL-8、IL-10和TNF-α的影响.方法:回顾性分析2015年8月至2016年10月在我院接受分娩的宫内感染产妇的早产儿的临床资料,同时选取同期在我院分娩的非宫内感染产妇的早产儿作为对照.观察两组早产儿血清炎症因子水平、NIHSS评分、肾功能、心肌酶指标和出生时一般情况的差异.结果:宫内感染组早产儿的IL-1β、IL-6、IL-8、IL-10和TNF-α水平均高于对照组(t=7.044、12.208、7.289、20.185、5.421,P＜0.001);宫内感染组早产儿的SpO2、PaO2低于对照组(t=-6.353、-35.142,P＜0.001),PaCO2水平高于对照组(t=35.720,P＜0.001);宫内感染组早产儿的NIHSS评分高于对照组(t=50.424,P＜0.001),出生1min和5min的Apgar评分低于对照组(t=-3.475、-4.398,P＜0.001);宫内感染组早产儿的尿素氮、肌酐和CK-MB水平均高于对照组(t=49.014、11.611、16.458,P＜0.001);Pearson相关分析法结果显示,宫内感染早产儿血清IL-1β、IL-6、IL-8、IL-10和TNF-α水平与NIHSS评分、肾功能、心肌酶指标水平正相关,与Apgar评分负相关.结论:宫内感染产妇分娩的早产儿的血IL-1β、IL-6、IL-8、IL-10和TNF-α水平较高,且与患儿的NIHSS评分、肾功能、心肌酶指标密切相关.