Analysis of Variola and Vaccinia Virus Neutralization Assays for Smallpox Vaccines

机译：天花疫苗的天花和牛痘病毒中和分析分析

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Possible smallpox reemergence drives research for third-generation vaccines that effectively neutralize variola virus. A comparison of neutralization assays using different substrates, variola and vaccinia (Dryvax and modified vaccinia Ankara [MVA]), showed significantly different 90% neutralization titers; Dryvax underestimated while MVA overestimated variola neutralization. Third-generation vaccines may rely upon neutralization as a correlate of protection.

机译：天花的再次出现可能推动有效地中和天花病毒的第三代疫苗的研究。使用不同底物，天花和牛痘（Dryvax和改良牛痘安卡拉[MVA]）进行中和测定的比较显示，中和效价存在90％的显着差异； Dryvax低估了，而MVA高估了天花的中和作用。第三代疫苗可能依赖于中和作为保护的相关因素。

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期刊名称 Clinical and Diagnostic Laboratory Immunology
作者
Christine M. Hughes; Frances K. Newman; Whitni B. Davidson; Victoria A. Olson; Scott K. Smith; Robert C. Holman; Lihan Yan; Sharon E. Frey; Robert B. Belshe; Kevin L. Karem; Inger K. Damon;
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年(卷),期 2012(19),7
年度 2012
页码 1116–1118
总页数 3
原文格式 PDF
正文语种
中图分类免疫学;
关键词
入库时间 2022-08-17 13:07:54

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专利

1. Analysis of Variola and Vaccinia Virus Neutralization Assays for Smallpox Vaccines [J] . Christine M. Hughes, Frances K. Newman, Whitni B. Davidson, Clinical and vaccine immunology: CVI . 2012,第7期

机译：天花疫苗的天花和牛痘病毒中和分析分析
2. A rapid, high-throughput vaccinia virus neutralization assay for testing smallpox vaccine efficacy based on detection of green fluorescent protein. [J] . Johnson MC, Damon IK, Karem KL Journal of Virological Methods . 2008,第1a2期

机译：一种快速，高通量牛痘病毒中和测定法，用于基于绿色荧光蛋白的检测来测试天花疫苗的功效。
3. Chimpanzee/human mAbs to vaccinia virus B5 protein neutralize vaccinia and smallpox viruses and protect mice against vaccinia virus [J] . Zhaochun Chen, Patricia Earl, Jeffrey Americo, Proceedings of the National Academy of Sciences of the United States of America . 2006,第6期

机译：黑猩猩/人单克隆抗体对牛痘病毒B5蛋白的作用可中和牛痘和天花病毒，并保护小鼠免受牛痘病毒
4. The Toxicity Evaluation of Recombinant Replicating Vaccinia Virus Vaccine in BALB/c Mice [C] . Sanglong WANG, Iimei CAO, Yin LIU, The 5th Session of the 13th annual meeting, CAST; Interantional conference on chemicals risk assessment of environmental hazard and human health. . 2011

机译：重组复制痘苗病毒疫苗对BALB / c小鼠的毒性评估
5. Vaccinia and Dengue viruses: Exploring current fundamental issues of memory T cells and utilizing quantitative immunology to compare correlates of protection following smallpox immunization. [D] . Ostrout, Nicholas Daniel. 2008

机译：牛痘和登革热病毒：探索当前记忆T细胞的基本问题，并利用定量免疫学比较天花免疫后的保护相关性。
6. Assay of neutralizing antibody against variola virus by the degree of focus reduction on HeLa cell cultures and its application to revaccination with smallpox vaccines of various potencies [O] . Takashi Kitamura, Nagashige Shinjo 1972

机译：通过减少对HeLa细胞培养物的关注程度来中和抗天花病毒抗体的方法及其在各种效力的天花疫苗的重新接种中的应用
7. Chimpanzee/human mAbs to vaccinia virus B5 protein neutralize vaccinia and smallpox viruses and protect mice against vaccinia virus [O] . Chen, Zhaochun, Earl, Patricia, Americo, Jeffrey, 2006

机译：黑猩猩/人单克隆抗体对牛痘病毒B5蛋白的作用可中和牛痘和天花病毒，并保护小鼠免受牛痘病毒

Analysis of Variola and Vaccinia Virus Neutralization Assays for Smallpox Vaccines

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