The Gut Microbiota in Multiple Sclerosis: An Overview of ClinicalTrials

摘要

Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating, anddegenerative disease that affects the central nervous system. A recent studyshowed that interaction between the immune system and the gut microbiota plays acrucial role in the development of MS. This review reports the clinical studiescarried out in recent years that aimed to evaluate the composition of themicrobiota in patients with relapsing–remitting MS (RR-MS). We also report whatis available in the literature regarding the effectiveness of fecal microbiotatransplantation and the role of the diet in restoring the intestinal bacterialpopulation. Studies report that patients with RR-MS have a microbiota that,compared with healthy controls, has higher amounts of , , , , , , , , and . Incontrast, MS patients have a microbiota with impoverished microbial populationsof , , , , , , , , , and . In conclusion, the restoration of themicrobial population in patients with RR-MS appears to reduce inflammatoryevents and the reactivation of the immune system.