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N-acetyltransferase 2 slow acetylator genotype associated with adverse effects of sulfasalazine in the treatment of inflammatory bowel disease

机译：N-乙酰转移酶2慢乙酰化基因型与柳氮磺胺吡啶治疗炎症性肠病的不良反应相关

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摘要

AIM:N-acetyltransferase 2 (NAT2) is an important enzyme catalyzing N-acetylation of sulfasalazine (SASP). The aim of the present study was to investigate associations of the genotypes of NAT2 with inflammatory bowel disease (IBD), and with adverse effects of SASP, which is used as the first-line treatment of IBD.

机译：目的：N-乙酰基转移酶2（NAT2）是一种重要的催化柳氮磺胺吡啶（SASP）N-乙酰化的酶。本研究的目的是研究NAT2基因型与炎症性肠病（IBD）以及SASP的不良反应之间的关联，SASP被用作IBD的一线治疗药物。

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期刊名称 Canadian Journal of Gastroenterology
作者
Min Chen; Bing Xia; Bixiao Chen; Qiusha Guo; Jin Li; Mei Ye; Zhengguo Hu;
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作者单位

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年(卷),期 2007(21),3
年度 2007
页码 155–158
总页数 4
原文格式 PDF
正文语种
中图分类肠道病毒与肝炎病毒;肝及胆疾病;肠疾病;
关键词
Adverse effects Genetic polymorphism Inflammatory bowel disease N-acetyltransferase 2 Sulfasalazine;

机译：不良反应;遗传多态性;炎性肠病;N-乙酰基转移酶2;柳氮磺吡啶;

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专利

1. N-acetyltransferase 2 slow acetylator genotype associated with adverse effects of sulphasalazine in the treatment of inflammatory bowel disease. [J] . Chen M, Xia B, Chen B, Canadian journal of gastroenterology . 2007,第3期

机译：N-乙酰转移酶2慢乙酰化基因型与柳氮磺吡啶在炎性肠病治疗中的不良反应有关。
2. N-acetyltransferase 2 slow acetylator genotype associated with adverse effects of sulphasalazine in the treatment of inflammatory bowel disease. [J] . Chen M, Xia B, Chen B, Canadian journal of gastroenterology . 2007,第3期

机译：N-乙酰转移酶2慢乙酰化基因型与柳氮磺吡啶在炎性肠病治疗中的不良反应有关。
3. Detailed genotyping demonstrates association between the slow acetylator genotype for N-acetyltransferase 2 (NAT2) and familial Parkinson's disease. [J] . Bandmann O, Vaughan JR, Holmans P, Movement disorders . 2000,第1期

机译：详细的基因分型表明N-乙酰基转移酶2（NAT2）的慢乙酰化基因型与家族性帕金森氏病之间存在关联。
4. Genotype-based classification of inflammatory bowel disease phenotype [C] . D. P. JEWEL Falk Symposium . 2007

机译：基于基于基因型炎症性肠病疾病表型分类
5. Novel Distinct Roles for Intestinal/Macrophage Cyclooxygenase 2 and Apolipoprotein Mimetic Peptides in the Development and Treatment of Inflammatory Bowel Diseases [D] . Meriwether, David. 2018

机译：肠道/巨噬细胞环氧合酶2和载脂蛋白模拟肽在炎症性肠病的发生和治疗中的新型独特作用
6. Correlation between Thiopurine S-Methyltransferase Genotype and Adverse Events in Inflammatory Bowel Disease Patients [O] . Davide Giuseppe Ribaldone, Alessandro Adriani, Gian Paolo Caviglia, 2019

机译：炎症性肠病患者硫嘌呤S-甲基转移酶基因型与不良事件的相关性
7. N-acetyltransferase 2 slow acetylator genotype associated with adverse effects of sulfasalazine in the treatment of inflammatory bowel disease [O] . Chen, Min, Xia, Bing, Chen, Bixiao, 2007

机译：N-乙酰转移酶2慢乙酰化基因型与柳氮磺胺吡啶治疗炎症性肠病的不良反应相关

N-acetyltransferase 2 slow acetylator genotype associated with adverse effects of sulfasalazine in the treatment of inflammatory bowel disease

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