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Applying a Dynamical Systems Model and Network Theory to Major Depressive Disorder

机译:动力学系统模型和网络理论在重性抑郁症中的应用

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摘要

Mental disorders like major depressive disorder can be modeled as complex dynamical systems. In this study we investigate the dynamic behavior of individuals to see whether or not we can expect a transition to another mood state. We introduce a mean field model to a binomial process, where we reduce a dynamic multidimensional system (stochastic cellular automaton) to a one-dimensional system to analyse the dynamics. Using maximum likelihood estimation, we can estimate the parameter of interest which, in combination with a bifurcation diagram, reflects the expectancy that someone has to transition to another mood state. After numerically illustrating the proposed method with simulated data, we apply this method to two empirical examples, where we show its use in a clinical sample consisting of patients diagnosed with major depressive disorder, and a general population sample. Results showed that the majority of the clinical sample was categorized as having an expectancy for a transition, while the majority of the general population sample did not have this expectancy. We conclude that the mean field model has great potential in assessing the expectancy for a transition between mood states. With some extensions it could, in the future, aid clinical therapists in the treatment of depressed patients.
机译:可以将诸如重度抑郁症之类的精神障碍建模为复杂的动力系统。在这项研究中,我们调查了个体的动态行为,以了解我们是否可以期望过渡到另一种情绪状态。我们将平均场模型引入二项式过程,其中将动态多维系统(随机细胞自动机)简化为一维系统以分析动力学。使用最大似然估计,我们可以估计感兴趣的参数,结合分叉图,该参数反映了某人必须过渡到另一种情绪状态的期望。在用模拟数据对所提出的方法进行数值说明之后,我们将该方法应用于两个经验示例,其中我们将其用于临床样本,其中包括诊断为重度抑郁症的患者和一般人群样本。结果表明,大多数临床样本被归类为具有过渡期的期望值,而大多数普通人群样本都没有这种期望值。我们得出结论,平均场模型在评估情绪状态之间转换的期望值方面具有巨大潜力。通过一些扩展,它可以在将来帮助临床治疗师治疗抑郁症患者。

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