Use of KCNQ Potassium Channel openers to reduce Symptoms or treating Disorders or conditions in which the system is cancelled item dopaminergic e.g. Schizophrenia and major depressive disorder

摘要

Requirement 1: reduce the symptoms of dopamine system disorder or a method to treat one or more disorders. In this method, dopamine system includes the host needed for management, an effective number of compounds, which can increase the ion flow through potassium knq channel. ILO Convention No. eighty-first: method according to any one of the requirements of Convention No. 1-80, wherein the compound is a compound in a formula in which R1 is selected from hydrogen, Alqu (en/in) ILO C1-6, cyclotwelve (EN) ILO C3-8, cyclotwelve (EN) ILO C3-8-Alqu (en/in) ILO C1-6, ACIL,C 1-6 hydroxy-alk (en / in) yl and C 3-8 hydroxy-cycloalk (en) yl; R2 and R2 'are independently selected from the group consisting of hydrogen, C1-6 alk (en / in) yl, C3-8 cycloalk (en) yl, aryl, C3-8 cycloalk (en) yl (en / in ) C1-6 yl, aryl-alk (en / in) yl C1-6, acyl, hydroxy-alk (en / in) yl C1-6 and hydroxy-cycloalk (en) yl C3-8; R3 is selected from the group consisting of hydrogen, C1-6 alk (en / in) yl, C3-8 cycloalkyl (en) yl, aryl, C3-8 cycloalk (en) yl-C1-8alkyl (en / in) yl 6, C1-6 aryl-alk (en / in) yl, C1-6 hydroxy-alk (en / in) yl, C3-8 aryl-cycloalk (en) yl, NR10R10'-C1 (alk / en / yl) yl -6, NR10R10'-C3-8 cycloalk (en) yl and C3-8 hydroxy-cycloalk (en) yl; where,R10 and R10 'are independently selected from the group consisting of hydrogen, C1-6 alk (en / in) yl, C3-8 cycloalk (en) yl, C3-8 cycloalk (en) yl (en / in) yl C1-6, hydroxy-alk (en / in) yl C1-6, hydroxy-cycloalk (en) yl C3-8, hydroxy-cycloalk (en) yl C3-8-alk (en / in) yl C1-6, C1-6 halo-alk (en / in) yl, C3-8 halo-cycloalk (en) yl, C3-8 halo-cycloalk (en) yl (C1-6-alk (en / in) yl, cyano-alk ( en / in) C1-6 yl, cyano-cycloalk (en) yl C3-8 and cyano-cycloalk (en) yl C3-8-alk (en / in) yl C1-6, or R10 and R10 'together with the The nitrogen atom to which they are attached forms a 4-8 membered saturated or unsaturated ring optionally containing 1, 2 or 3 additional heteroatoms;X is CO or SO2; Z is O or NR4, where R4 is selected from the group consisting of hydrogen, C1-6 alk (en / in) yl, C3-8 cycloalk (en) yl, C3-8 cycloalk (en) yl (en / in) C1-6 yl, hydroxy-alk (en / in) yl C1-6 and hydroxy-cycloalk (en) yl C3-8; or R3 and R4 together with the nitrogen atom to which they are attached form a 4-8 membered saturated or unsaturated ring optionally containing 1, 2 or 3 additional heteroatoms, the ring was formed with R3 and R4 and the nitrogen atom is optionally substituted with one or more substituents independently selected from C1-6 alk (en / in) yl, aryl, and aryl-C1-6 alk (en / in) yl; q is 0 or 1;e Y representa un heteroarilo de formula (2) o (3) donde W es O o S m es 0 1 2 o 3 n es 0 1 2 3 o 4 p es 0 o 1 y cada R5 est independientemente seleccionado del grupo que consiste Cyanogen, nitro, nr7r7,-S-R8, -SO2R8, SO2OR8 where R6 and R6 'are independently selected from the group consisting of hydrogen, C1-6 alk (en / in) yl, C3-8 cycloalk (en) yl, C3 cycloalk (en) yl -8-alk (en / in) yl C1-6 and aryl; R7 and R7 'are independently selected from the group consisting of hydrogen, C1-6 alk (en / in) yl, C3-8 cycloalk (en) yl, C3-8 cycloalk (en) yl (en / in) yl C1-6, aryl and acyl; and R8 is selected from the group consisting of C1-6 alk (en / in) yl, C3-8 cycloalk (en) yl, aryl, C3-8 cycloalk (en) yl-C1-6 alk (en / in) yl , aryl and -NR9R9 ';donde R9 y R9 est n independientemente seleccionados del grupo que consiste en hidrogeno alqu (en 2Fin) ilo cicloalqu (en) ilo C3-8 cicloalqu (en) ilo C3-8-alqu (en 2Fin) ilo C1-6 o sales farmac uticamente or R2 and R11 together with the nitrogen atom form a 5-8 membered saturated or unsaturated ring optionally containing 1, 2 or 3 additional heteroatoms; q is 0 or 1; X is CO or SO2 with the condition that q is 0 when X is SO2; Z is O or S; R1 is selected from the group consisting of hydrogen, C1-6 alk (en / in) yl, C3-8 cycloalk (en) yl, C3-8 cycloalk (en) yl, C1-6 alk (en / in) yl, acyl, hydroxy-alk (en / in) yl C1-6, hydroxy-cycloalk (en) yl C3-8, hydroxy-cycloalk (en) yl C3-8-alk (en / in) yl C1-6, halo- C1-6 alk (en / in) yl, C3-8 halo-cycloalk (en) yl, C3-8 halo-cycloalk (en) yl-C1-6 alk (en / in) yl,cyano-alk (en / in) yl cyano-cycloalk (en) yl C3-8 and cyano-cycloalk (en) yl C3-8-alk (en / in) yl C1-6; R2 is selected from the group consisting of hydrogen, C1-6 alk (en / in) yl, C3-8 cycloalk (en) yl, C3-8 cycloalk (en) yl, C1-6 alk (en / in) yl, Ar, Ar-alk (en / in) yl C1-6, Ar-cycloalk (en) yl C3-8, Ar-cycloalk (en) yl C3-8-alk (en / in) yl C1-6, acyl, hydroxy-alk (en / in) yl C1-6, hydroxy-cycloalk (en) yl C3-8, hydroxy-cycloalk (en) yl C3-8-alk (en / in) yl C1-6, halogen, halo- C1-6 alk (en / in) yl, C3-8 halo-cycloalkyl (en) yl, C3-8 alk-en (yl) cyclo-alk (en / in) yl, cyano, cyano-alk ( en / in) C1-6 yl, cyano-cycloalk (en) yl C3-8, cyano-cycloalk (en) yl C3-8-alk (en / in) yl C1-6,NR10R10'-C1-6 alk (en / in) yl, NR10R10'-C3-8 cycloalkyl (en) yl and NR3R10'-C3-8 cycloalk (en) yl (en / in) yl; where R10 and R10 'are independently selected from the group consisting of hydrogen, C1-6 alk (en / in) yl, C3-8 cycloalk (en) yl, C3-8 cycloalk (en) yl (en / in) C1-6 yl, hydroxy-alk (en / in) yl C1-6, hydroxy-cycloalk (en) yl C3-8, hydroxy-cycloalk (en) yl C3-8-alk (en / in) yl C1-6 , halo-alk (en / in) yl C1-6, halo-cycloalk (en) yl C3-8, halo-cycloalk (en) yl C3-8-alk (en / in) yl C1-6, cyano-alk (en / in) C1-6 yl, cyano-cycloalk (en) yl C3-8 and cyano-cycloalk (en) yl C3-8-alk (en / in) yl C1-6,O R10 and R10 'plus nitrate atoms form a saturated or unsaturated ring, which is composed of 5-8 members and optionally contains 1, 2 or 3 additional heteroatoms; if R2 is halogenated or cyanogen, then 0; if u is or s is 1 and R2, then or s is hydrogen or acid; 1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-e-6, AR, ar-alqu (EN / in) ILO C1-6, ar-cycloqu (EN) ILO C3-8,Ar-heterocycloalkyl (en) yl, Ar-cycloalkyl (en) yl C3-8-alk (en / in) yl C1-6, Ar-alk (en / in) yl C1-6-cycloalk (en) yl C3- 8, Ar-alk (en / in) yl C1-6-heterocycloalkyl (en) yl, alk (en / in) yloxy C1-6-alk (en / in) yl C1-6, cycloalk (en) yloxy C3- 8-C1-6 alk (en / in) yl, C1-6 alk (en / in) yloxy-C3-8 cycloalkyl (en) yl, C1-6 alk (en / in) yloxy-heterocycloalkyl (en) yl, Ar-oxy-alk (en / in) yl C1-6, Ar-alk (en / in) yloxy C1-6-alk (en / in) yl C1-6, alk (en / in) yloxy C1-6- carbonyl-alk (en / in) yl C1-6, cycloalk (en) yloxy C3-8-carbonyl-alk (en / in) yl C1-6, cycloalk (en) yl C3-8-alk (en / in) C1-6-yloxy-carbonyl-alk (en / in) yl C1-6, hydroxy-alk (en / in) yl C1-6, hydroxy-cycloalk (en) C3-8 yl, hydroxy-heterocycloalk (en) yl,hydroxy-cycloalkyl (en) yl C3-8-alk (en / in) yl C1-6, hydroxy-alk (en / in) yl C1-6-cycloalk (en) yl C3-8, hydroxy-alk (en / in) C1-6 yl-heterocycloalkyl (en) yl, halo-alk (en / in) yl C1-6, halo-cycloalk (en) C3-8 yl, halo-heterocycloalk (en) yl, halo-cycloalk ( ) C3-8-yl-alkyl (en / in) C1-6-yl, halo-alk (en / in) yl C1-6-cycloalk (en) C3-8-yl, halo-alk (en / in) yl C1- 6-heterocycloalkyl (en) yl, halo-alk (en / in) yl C1-6-Ar, halo-cycloalk (en) yl C3-8-Ar, halo-cycloalk (en) yl C3-8-alk (en / in) C1-6-yl ar, halo-alk (en / in) yl C1-6-cycloalk (en) yl C3-8-Ar, cyano-alk (en / in) yl C1-6, cyano-cycloalk (en) C3-8 yl, cyano-heterocycloalkyl (en) yl, cyano-cycloalk (en) yl C3-8-alk (en / in) yl C1-6,cyano-alk (en / in) yl C1-6-cycloalkyl (en) yl C3-8, cyano-alk (en / in) yl C1-6-heterocycloalk (en) yl, acyl-alk (en / in) yl C1-6, acyl-cycloalk (en) yl C3-8, acyl-heterocycloalkyl (en) yl, acyl-cycloalk (en) yl C3-8-alk (en / in) yl C1-6, acyl-alk (en / in) C1-6-yl-cycloalkyl (en) yl C3-8, acyl-alk (en / in) yl C1-6-heterocycloalk (en) yl, NR12R12 ',NR12R12 -alqu (en 2Fin) ilo C1-6 opcionalmente sustituido NR12R12 -cicloalqu (en) ilo C3-8 opcionalmente sustituido NR12R12 -cicloalqu (en) ilo C3-8-alqu (en 2Fin) ilo C1-6 opcionalmente sustituido donde R12 y hydroxy-cycloalkyl (en) yl C3-8-alk (en / in) yl C1-6, halo-alk (en / in) yl C1-6, halo-cycloalk (en) yl C3-8, halo-cycloalk ( en) C3-8-yl-alkyl (en / in) yl C1-6, cyano-alk (en / in) yl C1-6, cyano-cycloalk (en) yl C3-8 and cyano-cycloalk (en) yl C3 -8-alk (en / in) yl C1-6, or R12 and R12 'together with the nitrogen atom form a 5-8 membered saturated or unsaturated ring optionally containing 1, 2 or 3 additional heteroatoms; with the proviso that when R3 is NR12R12 'then q is 0; and Y represents a compound from the group of formulas (5);where the line represents a bond connecting the group represented by Y to the carbon atom; W is O or S; V is N, C or CH; T is N, NH or O; a is 0, 1, 2 or 3; b is 0, 1, 2, 3 or 4; c is 0 or 1; d is 0, 1, 2, or 3; e is 0, 1 or 2; f is 0, 1, 2, 3, 4, or 5; g is 0, 1, 2, 3 or