Whole body physiologically based modelling of β‐blockers in the rat: events in tissues and plasma following an i.v. bolus dose

摘要

Background and PurposeWhole body physiologically based pharmacokinetic (PBPK) models have been increasingly applied in drug development to describe kinetic events of therapeutic agents in animals and humans. The advantage of such modelling is the ability to incorporate vast amounts of physiological information, such as organ blood flow and volume, to ensure that the model is as close to reality as possible.