A novel individual‐cell‐based mathematical model based on multicellular tumour spheroids for evaluating doxorubicin‐related delivery in avascular regions

摘要

Background and PurposeEffective drug delivery in the avascular regions of tumours, which is crucial for the promising antitumour activity of doxorubicin‐related therapy, is governed by two inseparable processes: intercellular diffusion and intracellular retention. To accurately evaluate doxorubicin‐related delivery in the avascular regions, these two processes should be assessed together. Here we describe a new approach to such an assessment.