The hydrogen sulfide donor GYY4137 exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E−/− mice

摘要

Background and PurposeAtherosclerosis is associated with reduced vascular hydrogen sulfide (H2S) biosynthesis. GYY4137 is a novel slow-releasing H2S compound that may effectively mimic the time course of H2S release in vivo. However, it is not known whether GYY4137 affects atherosclerosis.