Inotropy and L-type Ca2+ current activated by β1- and β2-adrenoceptors are differently controlled by phosphodiesterases 3 and 4 in rat heart

机译：由β1-和β2-肾上腺素受体激活的正性肌力和L型Ca2 +电流受大鼠心脏磷酸二酯酶3和4的控制不同

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Background and purposeβ1- and β2-adrenoceptors coexist in rat heart but β2-adrenoceptor-mediated inotropic effects are hardly detectable, possibly due to phosphodiesterase (PDE) activity. We investigated the influence of the PDE3 inhibitor cilostamide (300 nmol·L⁻¹) and the PDE4 inhibitor rolipram (1 µmol·L⁻¹) on the effects of (−)-catecholamines.

机译：背景与目的β1-和β2-肾上腺素能受体在大鼠心脏中共存，但很难检测到β2-肾上腺素能受体介导的正性肌力作用，这可能是由于磷酸二酯酶（PDE）活性所致。我们研究了PDE3抑制剂西洛他酰胺（300nmol·L^{-1 ）和PDE4抑制剂rolipram（1 µmol·L ^{-1 ）对（- ）-儿茶酚胺。}}

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
Torsten Christ; Alejandro Galindo-Tovar; Marcus Thoms; Ursula Ravens; Alberto J Kaumann;
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作者单位

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年(卷),期 2009(156),1
年度 2009
页码 62–83
总页数 22
原文格式 PDF
正文语种
中图分类药学;
关键词
phosphodiesterases rat atrium sinoatrial node ventricle β1- and β2-adrenoceptors (−)-adrenaline (−)-noradrenaline calcium current;

机译：磷酸二酯酶;大鼠心房;窦房结;心室;β1-和β2-肾上腺素能受体;（-）-肾上腺素;（-）-去甲肾上腺素;钙电流;

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专利

1. Interleukin-1β Reduces L-type Ca2+ Current through Protein Kinase C? Activation in Mouse Heart [J] . Nabil El Khoury, Sophie Mathieu, Céline Fiset The Journal of biological chemistry . 2014,第32期

机译：白细胞介素-1β通过蛋白激酶C减少L型Ca2 +电流？鼠标心脏激活
2. Sarcolemmal Ca2+-entry through L-type Ca2+ channels controls the profile of Ca2+-activated Cl- current in canine ventricular myocytes [J] . Horvath Balks, Vaczi Krisztina, Hegyi Bence, Journal of Molecular and Cellular Cardiology . 2016,第Null期

机译：通过L型Ca2 +通道进入肌膜的Ca2 +可控制犬心室肌细胞中Ca2 +激活的Cl-电流的分布
3. Effect of β3-Adrenergic Receptor on Atrial L-type Ca2+ Current in Rats with Chronic Heart Failure [J] . LiB., ZhaoQ., WangL.-X., Heart, lung & circulation . 2014,第4期

机译：β3-肾上腺素能受体对慢性心力衰竭大鼠心房L型Ca2 +电流的影响
4. Effects of L-type Ca2+ channel blocker nifedipine on dynamic arterial blood pressure control [C] . Kawada Toru, Yamamoto Hiromi, Shimizu Shuji, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2013

机译：L型Ca 2 + / sup>通道阻滞剂硝丁平对动态动脉血压控制的影响
5. Intracellular regulation of sustained contraction stimulated by L-type Ca2+ channel activation in swine carotid smooth muscle. [D] . Ets, Hillevi K. 2016

机译：猪颈动脉平滑肌中L型Ca2 +通道激活刺激的持续收缩的细胞内调节。
6. Characterization of the cyclic nucleotide phosphodiesterase subtypes involved in the regulation of the L-type Ca2+ current in rat ventricular myocytes [O] . Ignacio Verde, Grégoire Vandecasteele, Frank Lezoualch, 1999

机译：参与大鼠心室肌细胞L型Ca2 +电流调节的环状核苷酸磷酸二酯酶亚型的表征
7. Inotropy and L-type Ca2+ current, activated by β1- and β2-adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heart [O] . Christ, Torsten, Galindo-Tovar, Alejandro, Thoms, Marcus, 2009

机译：由β1-和β2-肾上腺素受体激活的正性肌力和L型Ca2 +电流受大鼠心脏磷酸二酯酶3和4的控制不同

Inotropy and L-type Ca2+ current activated by β1- and β2-adrenoceptors are differently controlled by phosphodiesterases 3 and 4 in rat heart

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