Extended report: Major histocompatibility complex (MHC) class II alleles haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian African-American and Hispanic cases and 1000 controls

摘要

ObjectiveTo determine human leucocyte antigen-class II (HLA-class II) (DRB1, DQB1, DQA1 and DPB1) alleles, haplotypes and shared epitopes associated with scleroderma (systemic sclerosis (SSc)) and its subphenotypes in a large multi-ethnic US cohort by a case–control association study.