首页> 美国卫生研究院文献>BMJ Open Access >Extended report: MOR103 a human monoclonal antibody to granulocyte–macrophage colony-stimulating factor in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised double-blind placebo-controlled dose-escalation trial

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Extended report: MOR103 a human monoclonal antibody to granulocyte–macrophage colony-stimulating factor in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised double-blind placebo-controlled dose-escalation trial

机译：扩展报告：MOR103一种针对粒细胞-巨噬细胞集落刺激因子的人单克隆抗体在中度类风湿关节炎患者的治疗中：Ib / IIa期随机双盲安慰剂对照剂量递增试验的结果

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摘要

ObjectivesTo determine the safety, tolerability and signs of efficacy of MOR103, a human monoclonal antibody to granulocyte–macrophage colony-stimulating factor (GM-CSF), in patients with rheumatoid arthritis (RA).

机译：目的确定类风湿关节炎（RA）患者抗粒细胞-巨噬细胞集落刺激因子（GM-CSF）的人类单克隆抗体MOR103的安全性，耐受性和疗效标志。

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期刊名称 BMJ Open Access
作者
Frank Behrens; Paul P Tak; Mikkel Østergaard; Rumen Stoilov; Piotr Wiland; Thomas W Huizinga; Vadym Y Berenfus; Stoyanka Vladeva; Juergen Rech; Andrea Rubbert-Roth; Mariusz Korkosz; Dmitriy Rekalov; Igor A Zupanets; Bo J Ejbjerg; Jens Geiseler; Julia Fresenius; Roman P Korolkiewicz; Arndt J Schottelius; Harald Burkhardt;
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年(卷),期 -1(74),6
年度 -1
页码 1058–1064
总页数 7
原文格式 PDF
正文语种
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关键词
Rheumatoid Arthritis DMARDs (biologic) DAS28 Treatment;

机译：类风湿关节炎;DMARDs（生物的）;DAS28;治疗;

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专利

1. MOR103, a human monoclonal antibody to granulocyte-macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebo-controlled, dose-escalation trial [J] . Behrens Frank, Tak Paul P., Ostergaard Mikkel, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2015,第6期

机译：MOR103，一种针对粒细胞巨噬细胞集落刺激因子的人单克隆抗体，在中度类风湿关节炎患者的治疗中：Ib / IIa期随机，双盲，安慰剂对照，剂量递增试验的结果
2. Phase 1b randomized, double-blind study of namilumab, an anti-granulocyte macrophage colony-stimulating factor monoclonal antibody, in mild-to-moderate rheumatoid arthritis [J] . T. W. J. Huizinga, A. Batalov, R. Stoilov, Arthritis research & therapy. . 2017,第1期

机译：纳米单抗（一种抗粒细胞巨噬细胞集落刺激因子单克隆抗体）在轻度至中度类风湿关节炎中的1b阶段随机，双盲研究
3. Efficacy and safety of namilumab, a human monoclonal antibody against granulocyte-macrophage colony-stimulating factor (GM-CSF) ligand in patients with rheumatoid arthritis (RA) with either an inadequate response to background methotrexate therapy or an inadequate response or intolerance to an anti-TNF (tumour necrosis factor) biologic therapy: a randomized, controlled trial [J] . Peter C. Taylor, Didier Saurigny, Jiri Vencovsky, Arthritis research & therapy. . 2019,第1期

机译：抗风湿性关节炎（RA）患者对甲氨蝶呤背景疗法的反应不足，对抗氨甲蝶呤疗法的反应不足或不耐受的类风湿性关节炎（RA）患者抗粒细胞巨噬细胞集落刺激因子（GM-CSF）配体的人类单克隆抗体那米单抗的疗效和安全性-TNF（肿瘤坏死因子）生物疗法：一项随机对照试验
4. Extended report: Efficacy and safety of tabalumab an anti-BAFF monoclonal antibody in patients with moderate-to-severe rheumatoid arthritis and inadequate response to TNF inhibitors: results of a randomised double-blind placebo-controlled phase 3 study [O] . Michael Schiff, Bernard Combe, Thomas Dörner, 2015

机译：扩展报告：抗BAFF单克隆抗体塔巴木单抗对中度至重度类风湿性关节炎和对TNF抑制剂反应不足的患者的疗效和安全性：一项随机双盲安慰剂对照3期研究的结果
5. MOR103, a human monoclonal antibody to granulocyte-macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebo-controlled, dose-escalation trial [O] . Behrens, Frank, Tak, Paul P., Østergaard, Mikkel, 2015

机译：MOR103，一种针对粒细胞巨噬细胞集落刺激因子的人单克隆抗体，在中度类风湿关节炎患者的治疗中：Ib / IIa期随机，双盲，安慰剂对照，剂量递增试验的结果

Extended report: MOR103 a human monoclonal antibody to granulocyte–macrophage colony-stimulating factor in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised double-blind placebo-controlled dose-escalation trial

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